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10.4049/jimmunol.1401723 http://scihub22266oqcxt.onion/10.4049/jimmunol.1401723 C4201975!4201975 !25252961     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25252961 &cmd=llinks): Failed to open stream: HTTP request failed! 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Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells |pdf=|usr=}}{{25252961 }} gab.com Text Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25252961 #FOAvip Infusion of blood cells from a donor can induce humoral tolerance in a recipient and increase the probability of successful organ transplant, a clinical method defined as donor-specific transfusion (DST). Despite the clinical success of DST, the immunological mechanisms by which blood cells displaying a foreign Ag induce tolerance remain poorly understood. Based on recent findings showing that the B cell siglecs, CD22 and Siglec-G, can promote tolerance to Ags presented on the same surface as their ligands, we speculated that the B cell siglecs are key players in tolerance induced by DST. Using a variety of chemical and genetic approaches, we show that the B cell siglecs mediate tolerance to cell surface Ags by initiating an inhibitory signal that culminates in elimination of the Ag-reactive B cell. CD22 and Siglec-G are recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge. We speculate that this tolerogenic mechanism is a contributing factor in DST and a mechanism of peripheral B cell tolerance to cell surface autoantigens. Twit Text FOAVip Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25252961 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25252961 #FOAvip English Wikipedia <ref>{{Cite pmid|25252961 }}</ref> Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells #MMPMID25252961 Macauley MS ; Paulson JC J Immunol 2014[Nov]; 193 (9 ): 4312-21 PMID25252961 show ga Infusion of blood cells from a donor can induce humoral tolerance in a recipient and increase the probability of successful organ transplant, a clinical method defined as donor-specific transfusion (DST). Despite the clinical success of DST, the immunological mechanisms by which blood cells displaying a foreign Ag induce tolerance remain poorly understood. Based on recent findings showing that the B cell siglecs, CD22 and Siglec-G, can promote tolerance to Ags presented on the same surface as their ligands, we speculated that the B cell siglecs are key players in tolerance induced by DST. Using a variety of chemical and genetic approaches, we show that the B cell siglecs mediate tolerance to cell surface Ags by initiating an inhibitory signal that culminates in elimination of the Ag-reactive B cell. CD22 and Siglec-G are recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge. We speculate that this tolerogenic mechanism is a contributing factor in DST and a mechanism of peripheral B cell tolerance to cell surface autoantigens. |*Immune Tolerance [MESH] |Adoptive Transfer [MESH] |Animals [MESH] |Antigens, Surface/*immunology [MESH] |Antigens/immunology [MESH] |Apoptosis Regulatory Proteins/*metabolism [MESH] |Apoptosis/immunology [MESH] |B-Lymphocytes/*immunology/*metabolism [MESH] |Bcl-2-Like Protein 11 [MESH] |Immunity, Humoral [MESH] |Immunological Synapses/immunology/metabolism [MESH] |Lectins/genetics/*physiology [MESH] |Ligands [MESH] |Lymphocyte Activation/immunology [MESH] |Lymphocyte Depletion [MESH] |Membrane Proteins/*metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Proto-Oncogene Proteins/*metabolism [MESH] |Receptors, Antigen, B-Cell/genetics/*physiology [MESH] |Sialic Acid Binding Ig-like Lectin 2/genetics/*physiology [MESH] |Sialic Acid Binding Immunoglobulin-like Lectins [MESH]Siglecs induce tolerance to cell surface antigens by BIM-dependent del(epmc).pdf DeepDyve Pubget Overpricing