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10.1016/j.celrep.2014.08.008 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.08.008 C4201947!4201947!25199838     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2014 ; 8 (6): 2003-14 Nephropedia Template TP {{tp|p=25199838|t=2014. PTEN Interacts with Histone H1 and Controls Chromatin Condensation |pdf=|usr=}}{{25199838}} gab.com Text PTEN Interacts with Histone H1 and Controls Chromatin Condensation JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25199838 #FOAvip Chromatin organization and dynamics are integral to global gene transcription. Histone modification influences chromatin status and gene expression. PTEN plays multiple roles in tumor suppression, development and metabolism. Here we report on the interplay of PTEN, histone H1 and chromatin. We show that loss of PTEN leads to dissociation of histone H1 from chromatin and decondensation of chromatin. PTEN deletion also results in elevation of histone H4 acetylation at lysine 16, an epigenetic marker for chromatin activation. We found that PTEN and histone H1 physically interact through their C-terminal domains. Disruption of the PTEN C-terminus promotes the chromatin association of MOF acetyltransferase and induces H4K16 acetylation. Hyperacetylation of H4K16 impairs the association of PTEN with histone H1, which constitutes regulatory feedback that may deteriorate chromatin stability. Our results demonstrate that PTEN controls chromatin condensation, thus influencing gene expression. We propose that PTEN regulates global gene transcription profiling through histones and chromatin remodeling. Twit Text FOAVip PTEN Interacts with Histone H1 and Controls Chromatin Condensation ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25199838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25199838 #FOAvip English Wikipedia <ref>{{Cite pmid|25199838}}</ref> PTEN Interacts with Histone H1 and Controls Chromatin Condensation #MMPMID25199838 Chen ZH; Zhu M; Yang J; Liang H; He J; He S; Wang P; Kang X; McNutt MA; Yin Y; Shen WH Cell Rep 2014[Sep]; 8 (6): 2003-14 PMID25199838show ga Chromatin organization and dynamics are integral to global gene transcription. Histone modification influences chromatin status and gene expression. PTEN plays multiple roles in tumor suppression, development and metabolism. Here we report on the interplay of PTEN, histone H1 and chromatin. We show that loss of PTEN leads to dissociation of histone H1 from chromatin and decondensation of chromatin. PTEN deletion also results in elevation of histone H4 acetylation at lysine 16, an epigenetic marker for chromatin activation. We found that PTEN and histone H1 physically interact through their C-terminal domains. Disruption of the PTEN C-terminus promotes the chromatin association of MOF acetyltransferase and induces H4K16 acetylation. Hyperacetylation of H4K16 impairs the association of PTEN with histone H1, which constitutes regulatory feedback that may deteriorate chromatin stability. Our results demonstrate that PTEN controls chromatin condensation, thus influencing gene expression. We propose that PTEN regulates global gene transcription profiling through histones and chromatin remodeling. äPTEN Interacts with Histone H1 and Controls Chromatin Condensation (epmc).pdf DeepDyve Pubget Overpricing