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10.1111/nan.12146 http://scihub22266oqcxt.onion/10.1111/nan.12146 C4201886!4201886!24750178     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuropathol+Appl+Neurobiol 2015 ; 41 (4): 544-56 Nephropedia Template TP {{tp|p=24750178|t=2015. Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin?like growth factor?1 signalling |pdf=|usr=}}{{24750178}} gab.com Text Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin like growth factor 1 signalling JO: Neuropathol Appl Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=24750178 #FOAvip Aims: Use of enriched environment (EE) housing has been shown to promote recovery from cerebral ischaemic injury but the underlying mechanisms of their beneficial effects remains unclear. Here we examined whether the beneficial effects of EE housing on ischaemia?induced neurodegeneration and cognitive impairment are associated with increased insulin?like growth factor?1 (IGF?1) signalling in the hippocampus. Methods: Forty?two adult male Wistar rats were included in the study and received either ischaemia or sham surgery. Rats in each group were further randomized to either: EE or standard laboratory cage housing (control). Rats were placed in their assigned housing condition immediately after recovery from anaesthesia. Behavioural testing in the cued learning and discrimination learning tasks were conducted 2?weeks after ischaemia. Rats were euthanized after behavioural testing and the hippocampus was analysed for IGF?1 level, IGF?1 receptor (IGF?1R) activation, protein kinase B (Akt) pathway activation, neurone loss and caspase 3 expression. Results: Our data showed that EE housing: (1) mitigated ischaemia?induced neuronal loss; (2) attenuated ischaemia?induced increase in caspase 3 immunoreactivity in the hippocampus; (3) ameliorated ischaemia?induced cognitive impairments; and (4) increased IGF?1R activation and signalling through the Akt pathway after ischaemic injury. Conclusion: Ultimately, these findings suggest the possibility that IGF?1 signalling may be one of the underlying mechanisms involved in the beneficial effects of EE in optimizing recovery following cerebral ischaemic injury. Twit Text FOAVip Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin like growth factor 1 signalling ????Neuropathol Appl Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=24750178 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24750178 #FOAvip English Wikipedia <ref>{{Cite pmid|24750178}}</ref> Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin?like growth factor?1 signalling #MMPMID24750178 Wadowska M; Woods J; Rogozinska M; Briones TL Neuropathol Appl Neurobiol 2015[Jun]; 41 (4): 544-56 PMID24750178show ga Aims: Use of enriched environment (EE) housing has been shown to promote recovery from cerebral ischaemic injury but the underlying mechanisms of their beneficial effects remains unclear. Here we examined whether the beneficial effects of EE housing on ischaemia?induced neurodegeneration and cognitive impairment are associated with increased insulin?like growth factor?1 (IGF?1) signalling in the hippocampus. Methods: Forty?two adult male Wistar rats were included in the study and received either ischaemia or sham surgery. Rats in each group were further randomized to either: EE or standard laboratory cage housing (control). Rats were placed in their assigned housing condition immediately after recovery from anaesthesia. Behavioural testing in the cued learning and discrimination learning tasks were conducted 2?weeks after ischaemia. Rats were euthanized after behavioural testing and the hippocampus was analysed for IGF?1 level, IGF?1 receptor (IGF?1R) activation, protein kinase B (Akt) pathway activation, neurone loss and caspase 3 expression. Results: Our data showed that EE housing: (1) mitigated ischaemia?induced neuronal loss; (2) attenuated ischaemia?induced increase in caspase 3 immunoreactivity in the hippocampus; (3) ameliorated ischaemia?induced cognitive impairments; and (4) increased IGF?1R activation and signalling through the Akt pathway after ischaemic injury. Conclusion: Ultimately, these findings suggest the possibility that IGF?1 signalling may be one of the underlying mechanisms involved in the beneficial effects of EE in optimizing recovery following cerebral ischaemic injury. äNeuroprotective effects of enriched environment housing after transien(epmc).pdf DeepDyve Pubget Overpricing