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10.1007/s10858-014-9848-9 http://scihub22266oqcxt.onion/10.1007/s10858-014-9848-9 C4201884!4201884!25015532     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25015532&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomol+NMR 2014 ; 60 (1): 37-44 Nephropedia Template TP {{tp|p=25015532|t=2014. Comparison of the Sensitivities of WaterLOGSY and Saturation Transfer Difference NMR Experiments |pdf=|usr=}}{{25015532}} gab.com Text Comparison of the Sensitivities of WaterLOGSY and Saturation Transfer Difference NMR Experiments JO: J Biomol NMR http://www.kidney.de/pget.php?&tw=1&pmid=25015532 #FOAvip The WaterLOGSY (WL) and Saturation Transfer Difference (STD) NMR experiments have proven to be extremely useful techniques to characterize interactions between small molecules and large biomolecules. In this work we compare the relative sensitivities of WL and STD NMR using 3 experimental systems: ketoprofen (KET)-bovine serum albumin (BSA), tert-butyl hydroquinone (TBHQ)-hemagglutinin (HA), and chloramphenicol (CAM)-ribosome (70S). In all cases we find that WL is more sensitive than STD for a given experimental time with the ratios ranging from 3.2 for KET-BSA to 16 for TBHQ-HA and CAM-70S. We attribute the increased sensitivity of WL to be due to simultaneous saturation of multiple sources of cross correlation, including direct NOEs of 1H of water and exchangeable groups and indirect NOEs of 1H-C groups. We suggest that the outstanding sensitivity of WL make it ideally suited for drug screening efforts targeting very large biomolecules at relatively low concentrations. Twit Text FOAVip Comparison of the Sensitivities of WaterLOGSY and Saturation Transfer Difference NMR Experiments ????J Biomol NMR http://www.kidney.de/pget.php?&tw=1&pmid=25015532 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25015532 #FOAvip English Wikipedia <ref>{{Cite pmid|25015532}}</ref> Comparison of the Sensitivities of WaterLOGSY and Saturation Transfer Difference NMR Experiments #MMPMID25015532 Antanasijevic A; Ramirez B; Caffrey M J Biomol NMR 2014[Sep]; 60 (1): 37-44 PMID25015532show ga The WaterLOGSY (WL) and Saturation Transfer Difference (STD) NMR experiments have proven to be extremely useful techniques to characterize interactions between small molecules and large biomolecules. In this work we compare the relative sensitivities of WL and STD NMR using 3 experimental systems: ketoprofen (KET)-bovine serum albumin (BSA), tert-butyl hydroquinone (TBHQ)-hemagglutinin (HA), and chloramphenicol (CAM)-ribosome (70S). In all cases we find that WL is more sensitive than STD for a given experimental time with the ratios ranging from 3.2 for KET-BSA to 16 for TBHQ-HA and CAM-70S. We attribute the increased sensitivity of WL to be due to simultaneous saturation of multiple sources of cross correlation, including direct NOEs of 1H of water and exchangeable groups and indirect NOEs of 1H-C groups. We suggest that the outstanding sensitivity of WL make it ideally suited for drug screening efforts targeting very large biomolecules at relatively low concentrations. äComparison of the Sensitivities of WaterLOGSY and Saturation Transfer (epmc).pdf DeepDyve Pubget Overpricing