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10.1101/gad.243584.114

http://scihub22266oqcxt.onion/10.1101/gad.243584.114
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C4201291!4201291!25319830
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suck abstract from ncbi


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pmid25319830      Genes+Dev 2014 ; 28 (20): 2314-30
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  • Swi/Snf dynamics on stress-responsive genes is governed by competitive bromodomain interactions #MMPMID25319830
  • Dutta A; Gogol M; Kim JH; Smolle M; Venkatesh S; Gilmore J; Florens L; Washburn MP; Workman JL
  • Genes Dev 2014[Oct]; 28 (20): 2314-30 PMID25319830show ga
  • The Swi/Snf chromatin remodeling complex functions to alter nucleosome positions by either sliding nucleosomes on DNA or the eviction of histones. Dutta et al. find that acetylation of Snf2 regulates both recruitment and release of Swi/Snf from stress-responsive genes. The intramolecular interaction of the Snf2 bromodomain with the acetylated lysine residues on Snf2 negatively regulates binding and remodeling of acetylated nucleosomes by Swi/Snf. Activator-bound genes regulating metabolic processes showed greater retention of the Swi/Snf complex even when Snf2 was acetylated.
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