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10.1074/jbc.M114.555235

http://scihub22266oqcxt.onion/10.1074/jbc.M114.555235
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C4200259!4200259!25157100
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suck abstract from ncbi


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pmid25157100      J+Biol+Chem 2014 ; 289 (42): 29044-59
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  • Genome-wide Approaches Reveal Functional Vascular Endothelial Growth Factor (VEGF)-inducible Nuclear Factor of Activated T Cells (NFAT) c1 Binding to Angiogenesis-related Genes in the Endothelium* #MMPMID25157100
  • Suehiro Ji; Kanki Y; Makihara C; Schadler K; Miura M; Manabe Y; Aburatani H; Kodama T; Minami T
  • J Biol Chem 2014[Oct]; 289 (42): 29044-59 PMID25157100show ga
  • Background: VEGF-calcineurin-nuclear factor of activated T cells (NFAT) signaling regulates endothelial cell homeostasis.Results: Novel NFAT targets were identified by genome-wide screening and epigenome analysis.Conclusion: Inhibition of the NFAT targets led to blockade of VEGF-mediated functional angiogenesis.Significance: VEGF-NFAT genome-wide occupancy may be useful for the development of target therapies for VEGF-mediated vascular diseases.
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