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10.1074/jbc.M114.600783 http://scihub22266oqcxt.onion/10.1074/jbc.M114.600783 C4200256!4200256 !25204661     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25204661 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2014 ; 289 (42 ): 29001-13 Nephropedia Template TP {{tp|p=25204661 |t=2014. Transforming growth factor ?1 (TGF-?1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells |pdf=|usr=}}{{25204661 }} gab.com Text Transforming growth factor 1 (TGF- 1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25204661 #FOAvip Increased expression of transforming growth factor-?1 (TGF-?1) in glomerular mesangial cells (MC) augments extracellular matrix accumulation and hypertrophy during the progression of diabetic nephropathy (DN), a debilitating renal complication of diabetes. MicroRNAs (miRNAs) play key roles in the pathogenesis of DN by modulating the actions of TGF-?1 to enhance the expression of profibrotic genes like collagen. In this study, we found a significant decrease in the expression of miR-130b in mouse MC treated with TGF-?1. In parallel, there was a down-regulation in miR-130b host gene 2610318N02RIK (RIK), suggesting host gene-dependent expression of this miRNA. TGF-? receptor 1 (TGF-?R1) was identified as a target of miR-130b. Interestingly, the RIK promoter contains three NF-Y binding sites and was regulated by NF-YC. Furthermore, NF-YC expression was inhibited by TGF-?1, suggesting that a signaling cascade, involving TGF-?1-induced decreases in NF-YC, RIK, and miR-130b, may up-regulate TGF-?R1 to augment expression of TGF-?1 target fibrotic genes. miR-130b was down-regulated, whereas TGF-?R1, as well as the profibrotic genes collagen type IV ? 1 (Col4a1), Col12a1, CTGF, and PAI-1 were up-regulated not only in mouse MC treated with TGF-?1 but also in the glomeruli of streptozotocin-injected diabetic mice, supporting in vivo relevance. Together, these results demonstrate a novel miRNA- and host gene-mediated amplifying cascade initiated by TGF-?1 that results in the up-regulation of profibrotic factors, such as TGF-?R1 and collagens associated with the progression of DN. Twit Text FOAVip Transforming growth factor 1 (TGF- 1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25204661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25204661 #FOAvip English Wikipedia <ref>{{Cite pmid|25204661 }}</ref> Transforming growth factor ?1 (TGF-?1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells #MMPMID25204661 Castro NE ; Kato M ; Park JT ; Natarajan R J Biol Chem 2014[Oct]; 289 (42 ): 29001-13 PMID25204661 show ga Increased expression of transforming growth factor-?1 (TGF-?1) in glomerular mesangial cells (MC) augments extracellular matrix accumulation and hypertrophy during the progression of diabetic nephropathy (DN), a debilitating renal complication of diabetes. MicroRNAs (miRNAs) play key roles in the pathogenesis of DN by modulating the actions of TGF-?1 to enhance the expression of profibrotic genes like collagen. In this study, we found a significant decrease in the expression of miR-130b in mouse MC treated with TGF-?1. In parallel, there was a down-regulation in miR-130b host gene 2610318N02RIK (RIK), suggesting host gene-dependent expression of this miRNA. TGF-? receptor 1 (TGF-?R1) was identified as a target of miR-130b. Interestingly, the RIK promoter contains three NF-Y binding sites and was regulated by NF-YC. Furthermore, NF-YC expression was inhibited by TGF-?1, suggesting that a signaling cascade, involving TGF-?1-induced decreases in NF-YC, RIK, and miR-130b, may up-regulate TGF-?R1 to augment expression of TGF-?1 target fibrotic genes. miR-130b was down-regulated, whereas TGF-?R1, as well as the profibrotic genes collagen type IV ? 1 (Col4a1), Col12a1, CTGF, and PAI-1 were up-regulated not only in mouse MC treated with TGF-?1 but also in the glomeruli of streptozotocin-injected diabetic mice, supporting in vivo relevance. Together, these results demonstrate a novel miRNA- and host gene-mediated amplifying cascade initiated by TGF-?1 that results in the up-regulation of profibrotic factors, such as TGF-?R1 and collagens associated with the progression of DN. |*Gene Expression Regulation [MESH] |3' Untranslated Regions [MESH] |Animals [MESH] |CCAAT-Binding Factor/metabolism [MESH] |Cells, Cultured [MESH] |Collagen Type IV/metabolism [MESH] |Diabetic Nephropathies/*metabolism [MESH] |Disease Progression [MESH] |Fibrosis [MESH] |Kidney/metabolism [MESH] |Mesangial Cells/*metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |MicroRNAs/*metabolism [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptors, Transforming Growth Factor beta/*metabolism [MESH] |Signal Transduction [MESH]Transforming growth factor ?1 (TGF-?1) enhances expression of profibro(epmc).pdf DeepDyve Pubget Overpricing