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10.1038/bjc.2014.429 http://scihub22266oqcxt.onion/10.1038/bjc.2014.429 C4200084!4200084!25117815     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25117815&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Cancer 2014 ; 111 (8): 1657-62 Nephropedia Template TP {{tp|p=25117815|t=2014. Identification of 33 candidate oncogenes by screening for base-specific mutations |pdf=|usr=}}{{25117815}} gab.com Text Identification of 33 candidate oncogenes by screening for base-specific mutations JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25117815 #FOAvip Background:: Genes with recurrent codon-specific somatic mutations are likely drivers of tumorigenesis and potential therapeutic targets. Hypermutable cancers may represent a sensitive system for generation and selection of oncogenic mutations. Methods:: We utilised exome-sequencing data on 25 sporadic microsatellite-instable (MSI) colorectal cancers (CRCs) and searched for base-specific somatic mutation hotspots. Results:: We identified novel mutation hotspots in 33 genes. Fourteen genes displayed mutations in the validation set of 254 MSI CRCs: ANTXR1, MORC2, CEP135, CRYBB1, GALNT9, KRT82, PI15, SLC36A1, CNTF, GLDC, MBTPS1, OR9Q2, R3HDM1 and TTPAL. A database search found examples of the hotspot mutations in multiple cancer types. Conclusions:: This work reveals a variety of new recurrent candidate oncogene mutations to be further scrutinised as potential therapeutic targets. Twit Text FOAVip Identification of 33 candidate oncogenes by screening for base-specific mutations ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25117815 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25117815 #FOAvip English Wikipedia <ref>{{Cite pmid|25117815}}</ref> Identification of 33 candidate oncogenes by screening for base-specific mutations #MMPMID25117815 Tuupanen S; Hänninen UA; Kondelin J; von Nandelstadh P; Cajuso T; Gylfe AE; Katainen R; Tanskanen T; Ristolainen H; Böhm J; Mecklin JP; Järvinen H; Renkonen-Sinisalo L; Andersen CL; Taipale M; Taipale J; Vahteristo P; Lehti K; Pitkänen E; Aaltonen LA Br J Cancer 2014[Oct]; 111 (8): 1657-62 PMID25117815show ga Background:: Genes with recurrent codon-specific somatic mutations are likely drivers of tumorigenesis and potential therapeutic targets. Hypermutable cancers may represent a sensitive system for generation and selection of oncogenic mutations. Methods:: We utilised exome-sequencing data on 25 sporadic microsatellite-instable (MSI) colorectal cancers (CRCs) and searched for base-specific somatic mutation hotspots. Results:: We identified novel mutation hotspots in 33 genes. Fourteen genes displayed mutations in the validation set of 254 MSI CRCs: ANTXR1, MORC2, CEP135, CRYBB1, GALNT9, KRT82, PI15, SLC36A1, CNTF, GLDC, MBTPS1, OR9Q2, R3HDM1 and TTPAL. A database search found examples of the hotspot mutations in multiple cancer types. Conclusions:: This work reveals a variety of new recurrent candidate oncogene mutations to be further scrutinised as potential therapeutic targets. äIdentification of 33 candidate oncogenes by screening for base-specifi(epmc).pdf DeepDyve Pubget Overpricing