Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24948595
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+Immunol
2014 ; 26
(9
): 495-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Inflammasomes and intestinal homeostasis: regulating and connecting infection,
inflammation and the microbiota
#MMPMID24948595
Gagliani N
; Palm NW
; de Zoete MR
; Flavell RA
Int Immunol
2014[Sep]; 26
(9
): 495-9
PMID24948595
show ga
Inflammasomes are large cytosolic protein complexes that detect infection and
stress-associated signals and promote immediate inflammatory responses. In the
intestine, activation of the inflammasome leads to an inflammatory response that
is important for controlling enteric infections but can also result in
pathological tissue damage. Recent studies have suggested that the inflammasome
also regulates intestinal homeostasis through its effects on the intestinal
microbiota. Notably, many conflicting studies have been published regarding the
effect of inflammasome deficiencies on intestinal homeostasis. Here, we attempt
to reconcile these contrasting data by highlighting the many ways that the
inflammasome contributes to intestinal homeostasis and pathology and exploring
the potential role of alterations in the microbiota in these conflicting studies.