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10.1016/j.nbd.2014.04.001 http://scihub22266oqcxt.onion/10.1016/j.nbd.2014.04.001 C4199932!4199932!24746857     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurobiol+Dis 2014 ; 72PA (ä): 54-60 Nephropedia Template TP {{tp|p=24746857|t=2014. Alzheimer?s and ABC transporters - new opportunities for diagnostics and treatment |pdf=|usr=}}{{24746857}} gab.com Text Alzheimer s and ABC transporters - new opportunities for diagnostics and treatment JO: Neurobiol Dis http://www.kidney.de/pget.php?&tw=1&pmid=24746857 #FOAvip Much has been said about the increasing number of demented patients and the main risk factor ?age?. Frustratingly, we do not know the precise pattern and all modulating factors that provoke the pathologic changes in the brains of affected elderly. We have to diagnose early to be able to stop the progression of diseases that irreversibly destroy brain substance. Familiar AD cases have mislead some researchers for almost 20 years, which has unfortunately narrowed the scientific understanding and has, thus, lead to insufficient funding of independent approaches. Therefore, basic researchers hardly have been able to develop causative treatments and clinicians still do not have access to prognostic and early diagnostic tools.During the recent years it became clear that insufficient A? export, physiologically facilitated by the ABC transporter superfamily at the brain?s barriers, plays a fundamental role in disease initiation and progression. Furthermore, export mechanisms that are deficient in affected elderly are new targets for activation and, thus, treatment, but ideally also for prevention. In sporadic AD disturbed clearance of ?-amyloid from the brain is so far the most important factor for its accumulation in the parenchyma and vessel walls. Here, we review findings about the contribution of ABC transporters and of the perivascular drainage/glymphatic system on ?-amyloid clearance. We highlight their potential value for innovative early diagnostics using PET and describe recently described, effective ABC transporter-targeting agents as potential causative treatment for neurodegenerative proteopathies/dementias. Twit Text FOAVip Alzheimer s and ABC transporters - new opportunities for diagnostics and treatment ????Neurobiol Dis http://www.kidney.de/pget.php?&tw=1&pmid=24746857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24746857 #FOAvip English Wikipedia <ref>{{Cite pmid|24746857}}</ref> Alzheimer?s and ABC transporters - new opportunities for diagnostics and treatment #MMPMID24746857 Pahnke J; Langer O; Krohn M Neurobiol Dis 2014[Dec]; 72PA (ä): 54-60 PMID24746857show ga Much has been said about the increasing number of demented patients and the main risk factor ?age?. Frustratingly, we do not know the precise pattern and all modulating factors that provoke the pathologic changes in the brains of affected elderly. We have to diagnose early to be able to stop the progression of diseases that irreversibly destroy brain substance. Familiar AD cases have mislead some researchers for almost 20 years, which has unfortunately narrowed the scientific understanding and has, thus, lead to insufficient funding of independent approaches. Therefore, basic researchers hardly have been able to develop causative treatments and clinicians still do not have access to prognostic and early diagnostic tools.During the recent years it became clear that insufficient A? export, physiologically facilitated by the ABC transporter superfamily at the brain?s barriers, plays a fundamental role in disease initiation and progression. Furthermore, export mechanisms that are deficient in affected elderly are new targets for activation and, thus, treatment, but ideally also for prevention. In sporadic AD disturbed clearance of ?-amyloid from the brain is so far the most important factor for its accumulation in the parenchyma and vessel walls. Here, we review findings about the contribution of ABC transporters and of the perivascular drainage/glymphatic system on ?-amyloid clearance. We highlight their potential value for innovative early diagnostics using PET and describe recently described, effective ABC transporter-targeting agents as potential causative treatment for neurodegenerative proteopathies/dementias. äAlzheimer?s and ABC transporters - new opportunities for diagnostics a(epmc).pdf DeepDyve Pubget Overpricing