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10.1158/0008-5472.CAN-14-0764 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-0764 C4199906!4199906 !25261237     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25261237 &cmd=llinks): Failed to open stream: HTTP request failed! 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In vivo localization of ??Y and ¹??Lu radioimmunoconjugates using Cerenkov luminescence imaging in a disseminated murine leukemia model |pdf=|usr=}}{{25261237 }} gab.com Text In vivo localization of Y and ¹ Lu radioimmunoconjugates using Cerenkov luminescence imaging in a disseminated murine leukemia model JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25261237 #FOAvip Cerenkov radiation generated by positron-emitting radionuclides can be exploited for a molecular imaging technique known as Cerenkov luminescence imaging (CLI). Data have been limited, however, on the use of medium- to high-energy ?-emitting radionuclides of interest for cancer imaging and treatment. We assessed the use of CLI as an adjunct to determine localization of radioimmunoconjugates to hematolymphoid tissues. Radiolabeled (177)Lu- or (90)Y-anti-CD45 antibody (Ab; DOTA-30F11) was administered by tail vein injection to athymic mice bearing disseminated murine myeloid leukemia, with CLI images acquired at times afterward. Gamma counting of individual organs showed preferential uptake in CD45(+) tissues with significant retention of radiolabeled Ab in sites of leukemia (spleen and bone marrow). This result was confirmed in CLI images with 1.35 × 10(5) ± 2.2 × 10(4) p/s/cm(2)/sr and 3.45 × 10(3) ± 7.0 × 10(2) p/s/cm(2)/sr for (90)Y-DOTA-30F11 and (177)Lu-DOTA-30F11, respectively, compared with undetectable signal for both radionuclides using the nonbinding control Ab. Results showed that CLI allows for in vivo visualization of localized ?-emissions. Pixel intensity variability resulted from differences in absorbed doses of the associated energies of the ?-emitting radionuclide. Overall, our findings offer a preclinical proof of concept for the use of CLI techniques in tandem with currently available clinical diagnostic tools. Twit Text FOAVip In vivo localization of Y and ¹ Lu radioimmunoconjugates using Cerenkov luminescence imaging in a disseminated murine leukemia model ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25261237 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25261237 #FOAvip English Wikipedia <ref>{{Cite pmid|25261237 }}</ref> In vivo localization of ??Y and ¹??Lu radioimmunoconjugates using Cerenkov luminescence imaging in a disseminated murine leukemia model #MMPMID25261237 Balkin ER ; Kenoyer A ; Orozco JJ ; Hernandez A ; Shadman M ; Fisher DR ; Green DJ ; Hylarides MD ; Press OW ; Wilbur DS ; Pagel JM Cancer Res 2014[Oct]; 74 (20 ): 5846-54 PMID25261237 show ga Cerenkov radiation generated by positron-emitting radionuclides can be exploited for a molecular imaging technique known as Cerenkov luminescence imaging (CLI). Data have been limited, however, on the use of medium- to high-energy ?-emitting radionuclides of interest for cancer imaging and treatment. We assessed the use of CLI as an adjunct to determine localization of radioimmunoconjugates to hematolymphoid tissues. Radiolabeled (177)Lu- or (90)Y-anti-CD45 antibody (Ab; DOTA-30F11) was administered by tail vein injection to athymic mice bearing disseminated murine myeloid leukemia, with CLI images acquired at times afterward. Gamma counting of individual organs showed preferential uptake in CD45(+) tissues with significant retention of radiolabeled Ab in sites of leukemia (spleen and bone marrow). This result was confirmed in CLI images with 1.35 × 10(5) ± 2.2 × 10(4) p/s/cm(2)/sr and 3.45 × 10(3) ± 7.0 × 10(2) p/s/cm(2)/sr for (90)Y-DOTA-30F11 and (177)Lu-DOTA-30F11, respectively, compared with undetectable signal for both radionuclides using the nonbinding control Ab. Results showed that CLI allows for in vivo visualization of localized ?-emissions. Pixel intensity variability resulted from differences in absorbed doses of the associated energies of the ?-emitting radionuclide. Overall, our findings offer a preclinical proof of concept for the use of CLI techniques in tandem with currently available clinical diagnostic tools. |*Immunoconjugates [MESH] |*Radiopharmaceuticals/pharmacokinetics [MESH] |*Yttrium Radioisotopes/pharmacokinetics [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Leukemia/*diagnostic imaging [MESH] |Luminescent Measurements [MESH] |Lutetium [MESH] |Mice [MESH] |Phantoms, Imaging [MESH] |Radionuclide Imaging [MESH] |Spleen/metabolism [MESH]In vivo localization of ??Y and ¹??Lu radioimmunoconjugates using Cere(epmc).pdf DeepDyve Pubget Overpricing