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10.1007/s00251-014-0795-0 http://scihub22266oqcxt.onion/10.1007/s00251-014-0795-0 C4198446!4198446 !25124893     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25124893 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunogenetics 2014 ; 66 (11 ): 671-4 Nephropedia Template TP {{tp|p=25124893 |t=2014. Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc |pdf=|usr=}}{{25124893 }} gab.com Text Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc JO: Immunogenetics http://www.kidney.de/pget.php?&tw=1&pmid=25124893 #FOAvip Human sialic acid biology is unusual and thought to be unique among mammals. Humans lack a functional cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) protein and cannot synthesize the sugar Neu5Gc, an innate mammalian signal of self. Losing this sugar changed how humans interact with some of our deadliest pathogens: malaria, influenza, and streptococcus among others. We show that the New World monkeys, comprising the third of all primate species, have human-like sialic acid biology. They have lost Neu5Gc because of an independent CMAH inactivation ~30 million years ago (mya) (compared to ~3 mya in hominids). This parallel loss of Neu5Gc opens sialic acid biology to comparative phylogenetic analysis and reveals an unexpected conservation priority. New World monkeys risk infection by human pathogens that can recognize cells in the absence of Neu5Gc. This striking molecular convergence provides a mechanism that could explain the long-standing observation that New World monkeys are susceptible to some human diseases that cannot be transmitted to other primates. Twit Text FOAVip Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc ????Immunogenetics http://www.kidney.de/pget.php?&tw=1&pmid=25124893 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25124893 #FOAvip English Wikipedia <ref>{{Cite pmid|25124893 }}</ref> Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc #MMPMID25124893 Springer SA ; Diaz SL ; Gagneux P Immunogenetics 2014[Nov]; 66 (11 ): 671-4 PMID25124893 show ga Human sialic acid biology is unusual and thought to be unique among mammals. Humans lack a functional cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) protein and cannot synthesize the sugar Neu5Gc, an innate mammalian signal of self. Losing this sugar changed how humans interact with some of our deadliest pathogens: malaria, influenza, and streptococcus among others. We show that the New World monkeys, comprising the third of all primate species, have human-like sialic acid biology. They have lost Neu5Gc because of an independent CMAH inactivation ~30 million years ago (mya) (compared to ~3 mya in hominids). This parallel loss of Neu5Gc opens sialic acid biology to comparative phylogenetic analysis and reveals an unexpected conservation priority. New World monkeys risk infection by human pathogens that can recognize cells in the absence of Neu5Gc. This striking molecular convergence provides a mechanism that could explain the long-standing observation that New World monkeys are susceptible to some human diseases that cannot be transmitted to other primates. |Amino Acid Sequence [MESH] |Animals [MESH] |Antigens, Surface/*genetics [MESH] |Biological Evolution [MESH] |Carbohydrates/*genetics [MESH] |Cell Membrane/*genetics [MESH] |Humans [MESH] |Mixed Function Oxygenases/genetics [MESH] |Molecular Sequence Data [MESH] |N-Acetylneuraminic Acid/genetics [MESH] |Phylogeny [MESH] |Platyrrhini/*genetics [MESH]Parallel evolution of a self-signal: humans and new world monkeys inde(epmc).pdf DeepDyve Pubget Overpricing