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10.4161/auto.29647 http://scihub22266oqcxt.onion/10.4161/auto.29647 C4198361!4198361 !25126727     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25126727 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25126727 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Autophagy 2014 ; 10 (10 ): 1761-75 Nephropedia Template TP {{tp|p=25126727 |t=2014. Autophagy in microglia degrades extracellular ?-amyloid fibrils and regulates the NLRP3 inflammasome |pdf=|usr=}}{{25126727 }} gab.com Text Autophagy in microglia degrades extracellular -amyloid fibrils and regulates the NLRP3 inflammasome JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=25126727 #FOAvip Accumulation of ?-amyloid (A?) and resultant inflammation are critical pathological features of Alzheimer disease (AD). Microglia, a primary immune cell in brain, ingests and degrades extracellular A? fibrils via the lysosomal system. Autophagy is a catabolic process that degrades native cellular components, however, the role of autophagy in A? degradation by microglia and its effects on AD are unknown. Here we demonstrate a novel role for autophagy in the clearance of extracellular A? fibrils by microglia and in the regulation of the A?-induced NLRP3 (NLR family, pyrin domain containing 3) inflammasome using microglia specific atg7 knockout mice and cell cultures. We found in microglial cultures that A? interacts with MAP1LC3B-II via OPTN/optineurin and is degraded by an autophagic process mediated by the PRKAA1 pathway. We anticipate that enhancing microglial autophagy may be a promising new therapeutic strategy for AD. Twit Text FOAVip Autophagy in microglia degrades extracellular -amyloid fibrils and regulates the NLRP3 inflammasome ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=25126727 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25126727 #FOAvip English Wikipedia <ref>{{Cite pmid|25126727 }}</ref> Autophagy in microglia degrades extracellular ?-amyloid fibrils and regulates the NLRP3 inflammasome #MMPMID25126727 Cho MH ; Cho K ; Kang HJ ; Jeon EY ; Kim HS ; Kwon HJ ; Kim HM ; Kim DH ; Yoon SY Autophagy 2014[Oct]; 10 (10 ): 1761-75 PMID25126727 show ga Accumulation of ?-amyloid (A?) and resultant inflammation are critical pathological features of Alzheimer disease (AD). Microglia, a primary immune cell in brain, ingests and degrades extracellular A? fibrils via the lysosomal system. Autophagy is a catabolic process that degrades native cellular components, however, the role of autophagy in A? degradation by microglia and its effects on AD are unknown. Here we demonstrate a novel role for autophagy in the clearance of extracellular A? fibrils by microglia and in the regulation of the A?-induced NLRP3 (NLR family, pyrin domain containing 3) inflammasome using microglia specific atg7 knockout mice and cell cultures. We found in microglial cultures that A? interacts with MAP1LC3B-II via OPTN/optineurin and is degraded by an autophagic process mediated by the PRKAA1 pathway. We anticipate that enhancing microglial autophagy may be a promising new therapeutic strategy for AD. |*Autophagy [MESH] |AMP-Activated Protein Kinases/metabolism [MESH] |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Alzheimer Disease/metabolism/pathology [MESH] |Amyloid beta-Peptides/*metabolism [MESH] |Animals [MESH] |Autophagy-Related Protein 7 [MESH] |Carrier Proteins/*metabolism [MESH] |Cell Cycle Proteins [MESH] |Cell Line [MESH] |Extracellular Space/*metabolism [MESH] |Eye Proteins/metabolism [MESH] |Female [MESH] |Heat-Shock Proteins/metabolism [MESH] |Humans [MESH] |Inflammasomes/*metabolism [MESH] |Inflammation/pathology [MESH] |Integrases/metabolism [MESH] |Male [MESH] |Membrane Transport Proteins [MESH] |Mice [MESH] |Microglia/*metabolism/*pathology [MESH] |Microtubule-Associated Proteins/metabolism [MESH] |Models, Biological [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein [MESH] |Neurons/pathology [MESH] |Proteolysis [MESH] |Sequestosome-1 Protein [MESH]Autophagy in microglia degrades extracellular ?-amyloid fibrils and re(epmc).pdf DeepDyve Pubget Overpricing