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10.4161/auto.29568 http://scihub22266oqcxt.onion/10.4161/auto.29568 C4198357!4198357!25126723     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2014 ; 10 (10): 1712-25 Nephropedia Template TP {{tp|p=25126723|t=2014. The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy |pdf=|usr=}}{{25126723}} gab.com Text The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=25126723 #FOAvip Receptor-mediated mitophagy is one of the major mechanisms of mitochondrial quality control essential for cell survival. We previously have identified FUNDC1 as a mitophagy receptor for selectively removing damaged mitochondria in mammalian systems. A critical unanswered question is how receptor-mediated mitophagy is regulated in response to cellular and environmental cues. Here, we report the striking finding that BCL2L1/Bcl-xL, but not BCL2, suppresses mitophagy mediated by FUNDC1 through its BH3 domain. Mechanistically, we demonstrate that BCL2L1, but not BCL2, interacts with and inhibits PGAM5, a mitochondrially localized phosphatase, to prevent the dephosphorylation of FUNDC1 at serine 13 (Ser13), which activates hypoxia-induced mitophagy. Our results showed that the BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy in response to hypoxia and that BCL2L1 possesses unique functions distinct from BCL2. Twit Text FOAVip The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=25126723 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25126723 #FOAvip English Wikipedia <ref>{{Cite pmid|25126723}}</ref> The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy #MMPMID25126723 Wu H; Xue D; Chen G; Han Z; Huang L; Zhu C; Wang X; Jin H; Wang J; Zhu Y; Liu L; Chen Q Autophagy 2014[Oct]; 10 (10): 1712-25 PMID25126723show ga Receptor-mediated mitophagy is one of the major mechanisms of mitochondrial quality control essential for cell survival. We previously have identified FUNDC1 as a mitophagy receptor for selectively removing damaged mitochondria in mammalian systems. A critical unanswered question is how receptor-mediated mitophagy is regulated in response to cellular and environmental cues. Here, we report the striking finding that BCL2L1/Bcl-xL, but not BCL2, suppresses mitophagy mediated by FUNDC1 through its BH3 domain. Mechanistically, we demonstrate that BCL2L1, but not BCL2, interacts with and inhibits PGAM5, a mitochondrially localized phosphatase, to prevent the dephosphorylation of FUNDC1 at serine 13 (Ser13), which activates hypoxia-induced mitophagy. Our results showed that the BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy in response to hypoxia and that BCL2L1 possesses unique functions distinct from BCL2. äThe BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mi(epmc).pdf DeepDyve Pubget Overpricing