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10.4161/cam.28405 http://scihub22266oqcxt.onion/10.4161/cam.28405 C4198350!4198350!24642482     free     free     free       Cell+Adh+Migr 2014 ; 8 (3): 263-7 Nephropedia Template TP {{tp|p=24642482|t=2014. Spatial regulation of tumor cell protrusions by RhoC |pdf=|usr=}}{{24642482}} gab.com Text Spatial regulation of tumor cell protrusions by RhoC JO: Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=24642482 #FOAvip Systemic metastasis is the dissemination of cancer cells from the primary tumor to distant organs and is the primary cause of death in cancer patients. How do cancer cells leave the primary tumor mass? The ability of the tumor cells to form different types of actin-rich protrusions including invasive protrusions (invadopodia) and locomotory protrusions (lamellipodia [2D] or pseudopodia [3D]), facilitate the invasion and dissemination of the tumor cells. Rho-family of p21 small GTPases plays a direct role in regulating the actin dynamics in these intracellular compartments. Recent studies have shown that the signaling molecules including RhoC/p190RhoGEF/p190RhoGAP acts as a ?molecular compass? in order to direct the spatial and temporal dynamics of the formation of these invasive and locomotory protrusions leading to efficient invasion. Twit Text FOAVip Spatial regulation of tumor cell protrusions by RhoC ????Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=24642482 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24642482 #FOAvip English Wikipedia <ref>{{Cite pmid|24642482}}</ref> Spatial regulation of tumor cell protrusions by RhoC #MMPMID24642482 Bravo-Cordero JJ; Hodgson L; Condeelis JS Cell Adh Migr 2014[May]; 8 (3): 263-7 PMID24642482show ga Systemic metastasis is the dissemination of cancer cells from the primary tumor to distant organs and is the primary cause of death in cancer patients. How do cancer cells leave the primary tumor mass? The ability of the tumor cells to form different types of actin-rich protrusions including invasive protrusions (invadopodia) and locomotory protrusions (lamellipodia [2D] or pseudopodia [3D]), facilitate the invasion and dissemination of the tumor cells. Rho-family of p21 small GTPases plays a direct role in regulating the actin dynamics in these intracellular compartments. Recent studies have shown that the signaling molecules including RhoC/p190RhoGEF/p190RhoGAP acts as a ?molecular compass? in order to direct the spatial and temporal dynamics of the formation of these invasive and locomotory protrusions leading to efficient invasion. äSpatial regulation of tumor cell protrusions by RhoC (epmc).pdf DeepDyve Pubget Overpricing