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The interplay between the proteolytic, invasive, and adhesive domains of
invadopodia and their roles in cancer invasion
#MMPMID24714132
Revach OY
; Geiger B
Cell Adh Migr
2014[]; 8
(3
): 215-25
PMID24714132
show ga
Invadopodia are actin-based protrusions of the plasma membrane that penetrate
into the extracellular matrix (ECM), and enzymatically degrade it. Invadopodia
and podosomes, often referred to, collectively, as "invadosomes," are actin-based
membrane protrusions that facilitate matrix remodeling and cell invasion across
tissues, processes that occur under specific physiological conditions such as
bone remodeling, as well as under pathological states such as bone, immune
disorders, and cancer metastasis. In this review, we specifically focus on the
functional architecture of invadopodia in cancer cells; we discuss here three
functional domains of invadopodia responsible for the metalloproteinase-based
degradation of the ECM, the cytoskeleton-based mechanical penetration into the
matrix, and the integrin adhesome-based adhesion to the ECM. We will describe the
structural and molecular organization of each domain and the cross-talk between
them during the invasion process.
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