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10.4161/cam.27840 http://scihub22266oqcxt.onion/10.4161/cam.27840 C4198343!4198343!24714644     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Adh+Migr 2014 ; 8 (3): 192-204 Nephropedia Template TP {{tp|p=24714644|t=2014. Podosome organization drives osteoclast-mediated bone resorption |pdf=|usr=}}{{24714644}} gab.com Text Podosome organization drives osteoclast-mediated bone resorption JO: Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=24714644 #FOAvip Osteoclasts are the cells responsible for physiological bone resorption. A specific organization of their most prominent cytoskeletal structures, podosomes, is crucial for the degradation of mineralized bone matrix. Each podosome is constituted of an F-actin-enriched central core surrounded by a loose F-actin network, called the podosome cloud. In addition to intrinsic actin dynamics, podosomes are defined by their adhesion to the extracellular matrix, mainly via core-linking CD44 and cloud-linking integrins. These properties allow podosomes to collectively evolve into different patterns implicated in migration and bone resorption. Indeed, to resorb bone, osteoclasts polarize, actively secrete protons, and proteases into the resorption pit where these molecules are confined by a podosome-containing sealing zone. Here, we review recent advancements on podosome structure and regulatory pathways in osteoclasts. We also discuss the distinct functions of different podosome patterns during the lifespan of a single osteoclast. Twit Text FOAVip Podosome organization drives osteoclast-mediated bone resorption ????Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=24714644 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24714644 #FOAvip English Wikipedia <ref>{{Cite pmid|24714644}}</ref> Podosome organization drives osteoclast-mediated bone resorption #MMPMID24714644 Georgess D; Machuca-Gayet I; Blangy A; Jurdic P Cell Adh Migr 2014[May]; 8 (3): 192-204 PMID24714644show ga Osteoclasts are the cells responsible for physiological bone resorption. A specific organization of their most prominent cytoskeletal structures, podosomes, is crucial for the degradation of mineralized bone matrix. Each podosome is constituted of an F-actin-enriched central core surrounded by a loose F-actin network, called the podosome cloud. In addition to intrinsic actin dynamics, podosomes are defined by their adhesion to the extracellular matrix, mainly via core-linking CD44 and cloud-linking integrins. These properties allow podosomes to collectively evolve into different patterns implicated in migration and bone resorption. Indeed, to resorb bone, osteoclasts polarize, actively secrete protons, and proteases into the resorption pit where these molecules are confined by a podosome-containing sealing zone. Here, we review recent advancements on podosome structure and regulatory pathways in osteoclasts. We also discuss the distinct functions of different podosome patterns during the lifespan of a single osteoclast. äPodosome organization drives osteoclast-mediated bone resorption (epmc).pdf DeepDyve Pubget Overpricing