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10.15252/embr.201338233 http://scihub22266oqcxt.onion/10.15252/embr.201338233 C4198043!4198043!25074018     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2014 ; 15 (9): 991-9 Nephropedia Template TP {{tp|p=25074018|t=2014. Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms |pdf=|usr=}}{{25074018}} gab.com Text Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25074018 #FOAvip Regulatory T cells (Tregs) control autoreactive T cells by inhibiting activation-induced proliferation and cytokine expression. The molecular mechanisms responsible for the inactivation of effector T cells by Tregs remain yet to be fully characterized. We report that T-helper cells stimulated in the presence of Tregs quickly activate NFAT1 and have increased NFAT1-dependent expression of the transcription repressor Ikaros. NFAT1 deficiency or dominant-negative Ikaros compromises Treg-mediated inhibition of T-helper cells in vitro and in vivo. Thus, our results place NFAT-dependent mechanisms as general regulators of T-cell tolerance and show that Treg-mediated suppression of T-helper cells results from the activation of NFAT-regulated gene expression.Subject Categories: Immunology; Signal Transduction Twit Text FOAVip Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25074018 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25074018 #FOAvip English Wikipedia <ref>{{Cite pmid|25074018}}</ref> Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms #MMPMID25074018 Shin DS; Jordan A; Basu S; Thomas RM; Bandyopadhyay S; de Zoeten EF; Wells AD; Macian F EMBO Rep 2014[Sep]; 15 (9): 991-9 PMID25074018show ga Regulatory T cells (Tregs) control autoreactive T cells by inhibiting activation-induced proliferation and cytokine expression. The molecular mechanisms responsible for the inactivation of effector T cells by Tregs remain yet to be fully characterized. We report that T-helper cells stimulated in the presence of Tregs quickly activate NFAT1 and have increased NFAT1-dependent expression of the transcription repressor Ikaros. NFAT1 deficiency or dominant-negative Ikaros compromises Treg-mediated inhibition of T-helper cells in vitro and in vivo. Thus, our results place NFAT-dependent mechanisms as general regulators of T-cell tolerance and show that Treg-mediated suppression of T-helper cells results from the activation of NFAT-regulated gene expression.Subject Categories: Immunology; Signal Transduction äRegulatory T cells suppress CD4+ T cells through NFAT-dependent transc(epmc).pdf DeepDyve Pubget Overpricing