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10.1002/embj.201387329 http://scihub22266oqcxt.onion/10.1002/embj.201387329 C4198027!4198027!24797475     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2014 ; 33 (11): 1243-55 Nephropedia Template TP {{tp|p=24797475|t=2014. STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis |pdf=|usr=}}{{24797475}} gab.com Text STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=24797475 #FOAvip Cohesion between sister chromatids in mitotic and meiotic cells is promoted by a ring-shaped protein structure, the cohesin complex. The cohesin core complex is composed of four subunits, including two structural maintenance of chromosome (SMC) proteins, one ?-kleisin protein, and one SA protein. Meiotic cells express both mitotic and meiosis-specific cohesin core subunits, generating cohesin complexes with different subunit composition and possibly separate meiotic functions. Here, we have analyzed the in vivo function of STAG3, a vertebrate meiosis-specific SA protein. Mice with a hypomorphic allele of Stag3, which display a severely reduced level of STAG3, are viable but infertile. We show that meiocytes in homozygous mutant Stag3 mice display chromosome axis compaction, aberrant synapsis, impaired recombination and developmental arrest. We find that the three different ?-kleisins present in meiotic cells show different dosage-dependent requirements for STAG3 and that STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions. Twit Text FOAVip STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=24797475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24797475 #FOAvip English Wikipedia <ref>{{Cite pmid|24797475}}</ref> STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis #MMPMID24797475 Fukuda T; Fukuda N; Agostinho A; Hernández-Hernández A; Kouznetsova A; Höög C EMBO J 2014[Jun]; 33 (11): 1243-55 PMID24797475show ga Cohesion between sister chromatids in mitotic and meiotic cells is promoted by a ring-shaped protein structure, the cohesin complex. The cohesin core complex is composed of four subunits, including two structural maintenance of chromosome (SMC) proteins, one ?-kleisin protein, and one SA protein. Meiotic cells express both mitotic and meiosis-specific cohesin core subunits, generating cohesin complexes with different subunit composition and possibly separate meiotic functions. Here, we have analyzed the in vivo function of STAG3, a vertebrate meiosis-specific SA protein. Mice with a hypomorphic allele of Stag3, which display a severely reduced level of STAG3, are viable but infertile. We show that meiocytes in homozygous mutant Stag3 mice display chromosome axis compaction, aberrant synapsis, impaired recombination and developmental arrest. We find that the three different ?-kleisins present in meiotic cells show different dosage-dependent requirements for STAG3 and that STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions. äSTAG3-mediated stabilization of REC8 cohesin complexes promotes chromo(epmc).pdf DeepDyve Pubget Overpricing