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10.15252/embr.201438638

http://scihub22266oqcxt.onion/10.15252/embr.201438638
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C4197875!4197875!24825474
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suck abstract from ncbi


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pmid24825474      EMBO+Rep 2014 ; 15 (6): 642-56
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  • The Hippo signaling pathway in stem cell biology and cancer #MMPMID24825474
  • Mo JS; Park HW; Guan KL
  • EMBO Rep 2014[Jun]; 15 (6): 642-56 PMID24825474show ga
  • The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue homeostasis and organ size control by regulating tissue-specific stem cells. Moreover, this pathway plays a prominent role in tissue repair and regeneration. Dysregulation of the Hippo pathway is associated with cancer development. Recent studies have revealed a complex network of upstream inputs, including cell density, mechanical sensation, and G-protein-coupled receptor (GPCR) signaling, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway in stem cell biology and its potential implications in tissue homeostasis and cancer.
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