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2014 ; 59
(20
): 6251-66
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Reconstructing cone-beam CT with spatially varying qualities for adaptive
radiotherapy: a proof-of-principle study
#MMPMID25255957
Lu W
; Yan H
; Gu X
; Tian Z
; Luo O
; Yang L
; Zhou L
; Cervino L
; Wang J
; Jiang S
; Jia X
Phys Med Biol
2014[Oct]; 59
(20
): 6251-66
PMID25255957
show ga
With the aim of maximally reducing imaging dose while meeting requirements for
adaptive radiation therapy (ART), we propose in this paper a new cone beam CT
(CBCT) acquisition and reconstruction method that delivers images with a low
noise level inside a region of interest (ROI) and a relatively high noise level
outside the ROI. The acquired projection images include two groups: densely
sampled projections at a low exposure with a large field of view (FOV) and
sparsely sampled projections at a high exposure with a small FOV corresponding to
the ROI. A new algorithm combining the conventional filtered back-projection
algorithm and the tight-frame iterative reconstruction algorithm is also designed
to reconstruct the CBCT based on these projection data. We have validated our
method on a simulated head-and-neck (HN) patient case, a semi-real experiment
conducted on a HN cancer patient under a full-fan scan mode, as well as a Catphan
phantom under a half-fan scan mode. Relative root-mean-square errors (RRMSEs) of
less than 3% for the entire image and ~1% within the ROI compared to the ground
truth have been observed. These numbers demonstrate the ability of our proposed
method to reconstruct high-quality images inside the ROI. As for the part outside
ROI, although the images are relatively noisy, it can still provide sufficient
information for radiation dose calculations in ART. Dose distributions calculated
on our CBCT image and on a standard CBCT image are in agreement, with a mean
relative difference of 0.082% inside the ROI and 0.038% outside the ROI. Compared
with the standard clinical CBCT scheme, an imaging dose reduction of
approximately 3-6 times inside the ROI was achieved, as well as an 8 times
outside the ROI. Regarding computational efficiency, it takes 1-3?min to
reconstruct a CBCT image depending on the number of projections used. These
results indicate that the proposed method has the potential for application in
ART.
|*Algorithms
[MESH]
|Cone-Beam Computed Tomography/*methods
[MESH]
|Head and Neck Neoplasms/*diagnostic imaging/radiotherapy
[MESH]