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10.1242/dev.104794

http://scihub22266oqcxt.onion/10.1242/dev.104794
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C4197615!4197615!25005470
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suck abstract from ncbi


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pmid25005470      Development 2014 ; 141 (14): 2750-9
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  • Cellular and physical mechanisms of branching morphogenesis #MMPMID25005470
  • Varner VD; Nelson CM
  • Development 2014[Jul]; 141 (14): 2750-9 PMID25005470show ga
  • Branching morphogenesis is the developmental program that builds the ramified epithelial trees of various organs, including the airways of the lung, the collecting ducts of the kidney, and the ducts of the mammary and salivary glands. Even though the final geometries of epithelial trees are distinct, the molecular signaling pathways that control branching morphogenesis appear to be conserved across organs and species. However, despite this molecular homology, recent advances in cell lineage analysis and real-time imaging have uncovered surprising differences in the mechanisms that build these diverse tissues. Here, we review these studies and discuss the cellular and physical mechanisms that can contribute to branching morphogenesis.
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