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10.1083/jcb.201406037 http://scihub22266oqcxt.onion/10.1083/jcb.201406037 C4195833!4195833 !25287301     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25287301 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2014 ; 207 (1 ): 41-57 Nephropedia Template TP {{tp|p=25287301 |t=2014. The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation |pdf=|usr=}}{{25287301 }} gab.com Text The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25287301 #FOAvip How cells shape and remodel organelles in response to cellular signals is a poorly understood process. Using Xenopus laevis egg extract, we found that increases in cytosolic calcium lead to the activation of an endogenous ribonuclease, XendoU. A fraction of XendoU localizes to the endoplasmic reticulum (ER) and is required for nuclear envelope assembly and ER network formation in a catalysis-dependent manner. Using a purified vesicle fusion assay, we show that XendoU functions on the surface of ER membranes to promote RNA cleavage and ribonucleoprotein (RNP) removal. Additionally, RNA removal from the surface of vesicles by RNase treatment leads to increased ER network formation. Using human tissue culture cells, we found that hEndoU localizes to the ER, where it promotes the formation of ER tubules in a catalysis-dependent manner. Together, these results demonstrate that calcium-activated removal of RNA from membranes by XendoU promotes and refines ER remodeling and the formation of tubular ER. Twit Text FOAVip The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25287301 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25287301 #FOAvip English Wikipedia <ref>{{Cite pmid|25287301 }}</ref> The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation #MMPMID25287301 Schwarz DS ; Blower MD J Cell Biol 2014[Oct]; 207 (1 ): 41-57 PMID25287301 show ga How cells shape and remodel organelles in response to cellular signals is a poorly understood process. Using Xenopus laevis egg extract, we found that increases in cytosolic calcium lead to the activation of an endogenous ribonuclease, XendoU. A fraction of XendoU localizes to the endoplasmic reticulum (ER) and is required for nuclear envelope assembly and ER network formation in a catalysis-dependent manner. Using a purified vesicle fusion assay, we show that XendoU functions on the surface of ER membranes to promote RNA cleavage and ribonucleoprotein (RNP) removal. Additionally, RNA removal from the surface of vesicles by RNase treatment leads to increased ER network formation. Using human tissue culture cells, we found that hEndoU localizes to the ER, where it promotes the formation of ER tubules in a catalysis-dependent manner. Together, these results demonstrate that calcium-activated removal of RNA from membranes by XendoU promotes and refines ER remodeling and the formation of tubular ER. |*RNA Stability [MESH] |Animals [MESH] |Calcium Signaling [MESH] |Calcium/metabolism [MESH] |Cell Line [MESH] |Cell Membrane/enzymology/metabolism [MESH] |Endoplasmic Reticulum/*metabolism [MESH] |Endoribonucleases/*metabolism [MESH] |HeLa Cells [MESH] |Humans [MESH] |Nuclear Envelope/*metabolism [MESH] |Ovum/metabolism [MESH] |RNA Interference [MESH] |RNA, Messenger/*metabolism [MESH] |RNA, Small Interfering/genetics [MESH] |Ribonucleoproteins/metabolism [MESH] |Signal Transduction/genetics [MESH] |Xenopus Proteins/*metabolism [MESH]The calcium-dependent ribonuclease XendoU promotes ER network formatio(epmc).pdf DeepDyve Pubget Overpricing