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10.1083/jcb.201406140 http://scihub22266oqcxt.onion/10.1083/jcb.201406140 C4195830!4195830 !25313408     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25313408 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2014 ; 207 (1 ): 123-37 Nephropedia Template TP {{tp|p=25313408 |t=2014. Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation |pdf=|usr=}}{{25313408 }} gab.com Text Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25313408 #FOAvip Airway multiciliated epithelial cells play crucial roles in the mucosal defense system, but their differentiation process remains poorly understood. Mice lacking the basal body component Chibby (Cby) exhibit impaired mucociliary transport caused by defective ciliogenesis, resulting in chronic airway infection. In this paper, using primary cultures of mouse tracheal epithelial cells, we show that Cby facilitates basal body docking to the apical cell membrane through proper formation of ciliary vesicles at the distal appendage during the early stages of ciliogenesis. Cby is recruited to the distal appendages of centrioles via physical interaction with the distal appendage protein CEP164. Cby then associates with the membrane trafficking machinery component Rabin8, a guanine nucleotide exchange factor for the small guanosine triphosphatase Rab8, to promote recruitment of Rab8 and efficient assembly of ciliary vesicles. Thus, our study identifies Cby as a key regulator of ciliary vesicle formation and basal body docking during the differentiation of airway ciliated cells. Twit Text FOAVip Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25313408 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25313408 #FOAvip English Wikipedia <ref>{{Cite pmid|25313408 }}</ref> Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation #MMPMID25313408 Burke MC ; Li FQ ; Cyge B ; Arashiro T ; Brechbuhl HM ; Chen X ; Siller SS ; Weiss MA ; O'Connell CB ; Love D ; Westlake CJ ; Reynolds SD ; Kuriyama R ; Takemaru K J Cell Biol 2014[Oct]; 207 (1 ): 123-37 PMID25313408 show ga Airway multiciliated epithelial cells play crucial roles in the mucosal defense system, but their differentiation process remains poorly understood. Mice lacking the basal body component Chibby (Cby) exhibit impaired mucociliary transport caused by defective ciliogenesis, resulting in chronic airway infection. In this paper, using primary cultures of mouse tracheal epithelial cells, we show that Cby facilitates basal body docking to the apical cell membrane through proper formation of ciliary vesicles at the distal appendage during the early stages of ciliogenesis. Cby is recruited to the distal appendages of centrioles via physical interaction with the distal appendage protein CEP164. Cby then associates with the membrane trafficking machinery component Rabin8, a guanine nucleotide exchange factor for the small guanosine triphosphatase Rab8, to promote recruitment of Rab8 and efficient assembly of ciliary vesicles. Thus, our study identifies Cby as a key regulator of ciliary vesicle formation and basal body docking during the differentiation of airway ciliated cells. |Amino Acid Motifs/genetics [MESH] |Animals [MESH] |Basal Bodies/physiology [MESH] |Carrier Proteins/genetics/*metabolism [MESH] |Cell Differentiation [MESH] |Cell Line, Tumor [MESH] |Cell Membrane/metabolism [MESH] |Centrioles/physiology [MESH] |Cilia/genetics/*metabolism [MESH] |Epithelial Cells/*cytology [MESH] |Germinal Center Kinases [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Microtubule Proteins/genetics/*metabolism [MESH] |Mucociliary Clearance/genetics [MESH] |Naphthalenes [MESH] |Nuclear Proteins/genetics/*metabolism [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Protein Structure, Tertiary [MESH] |Protein Transport [MESH] |RNA Interference [MESH] |RNA, Small Interfering [MESH] |Respiratory Mucosa/*cytology [MESH]Chibby promotes ciliary vesicle formation and basal body docking durin(epmc).pdf DeepDyve Pubget Overpricing