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10.15252/embj.201487826 http://scihub22266oqcxt.onion/10.15252/embj.201487826 C4195789!4195789!25024437     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2014 ; 33 (17): 1960-76 Nephropedia Template TP {{tp|p=25024437|t=2014. Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation |pdf=|usr=}}{{25024437}} gab.com Text Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25024437 #FOAvip The antimitotic anti-cancer drugs, including taxol, perturb spindle dynamics, and induce prolonged, spindle checkpoint-dependent mitotic arrest in cancer cells. These cells then either undergo apoptosis triggered by the intrinsic mitochondrial pathway or exit mitosis without proper cell division in an adaptation pathway. Using a genome-wide small interfering RNA (siRNA) screen in taxol-treated HeLa cells, we systematically identify components of the mitotic apoptosis and adaptation pathways. We show that the Mad2 inhibitor p31comet actively promotes mitotic adaptation through cyclin B1 degradation and has a minor separate function in suppressing apoptosis. Conversely, the pro-apoptotic Bcl2 family member, Noxa, is a critical initiator of mitotic cell death. Unexpectedly, the upstream components of the mitochondrial apoptosis pathway and the mitochondrial fission protein Drp1 contribute to mitotic adaption. Our results reveal crosstalk between the apoptosis and adaptation pathways during mitotic arrest. Twit Text FOAVip Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25024437 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25024437 #FOAvip English Wikipedia <ref>{{Cite pmid|25024437}}</ref> Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation #MMPMID25024437 Díaz-Martínez LA; Karamysheva ZN; Warrington R; Li B; Wei S; Xie XJ; Roth MG; Yu H EMBO J 2014[Sep]; 33 (17): 1960-76 PMID25024437show ga The antimitotic anti-cancer drugs, including taxol, perturb spindle dynamics, and induce prolonged, spindle checkpoint-dependent mitotic arrest in cancer cells. These cells then either undergo apoptosis triggered by the intrinsic mitochondrial pathway or exit mitosis without proper cell division in an adaptation pathway. Using a genome-wide small interfering RNA (siRNA) screen in taxol-treated HeLa cells, we systematically identify components of the mitotic apoptosis and adaptation pathways. We show that the Mad2 inhibitor p31comet actively promotes mitotic adaptation through cyclin B1 degradation and has a minor separate function in suppressing apoptosis. Conversely, the pro-apoptotic Bcl2 family member, Noxa, is a critical initiator of mitotic cell death. Unexpectedly, the upstream components of the mitochondrial apoptosis pathway and the mitochondrial fission protein Drp1 contribute to mitotic adaption. Our results reveal crosstalk between the apoptosis and adaptation pathways during mitotic arrest. äGenome-wide siRNA screen reveals coupling between mitotic apoptosis an(epmc).pdf DeepDyve Pubget Overpricing