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10.15252/embj.201487870 http://scihub22266oqcxt.onion/10.15252/embj.201487870 C4195786!4195786 !25024434     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25024434 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2014 ; 33 (17 ): 1912-27 Nephropedia Template TP {{tp|p=25024434 |t=2014. K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation |pdf=|usr=}}{{25024434 }} gab.com Text K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25024434 #FOAvip Neuronal histone acetylation has been linked to memory consolidation, and targeting histone acetylation has emerged as a promising therapeutic strategy for neuropsychiatric diseases. However, the role of histone-modifying enzymes in the adult brain is still far from being understood. Here we use RNA sequencing to screen the levels of all known histone acetyltransferases (HATs) in the hippocampal CA1 region and find that K-acetyltransferase 2a (Kat2a)--a HAT that has not been studied for its role in memory function so far--shows highest expression. Mice that lack Kat2a show impaired hippocampal synaptic plasticity and long-term memory consolidation. We furthermore show that Kat2a regulates a highly interconnected hippocampal gene expression network linked to neuroactive receptor signaling via a mechanism that involves nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B). In conclusion, our data establish Kat2a as a novel and essential regulator of hippocampal memory consolidation. Twit Text FOAVip K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25024434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25024434 #FOAvip English Wikipedia <ref>{{Cite pmid|25024434 }}</ref> K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation #MMPMID25024434 Stilling RM ; Rönicke R ; Benito E ; Urbanke H ; Capece V ; Burkhardt S ; Bahari-Javan S ; Barth J ; Sananbenesi F ; Schütz AL ; Dyczkowski J ; Martinez-Hernandez A ; Kerimoglu C ; Dent SY ; Bonn S ; Reymann KG ; Fischer A EMBO J 2014[Sep]; 33 (17 ): 1912-27 PMID25024434 show ga Neuronal histone acetylation has been linked to memory consolidation, and targeting histone acetylation has emerged as a promising therapeutic strategy for neuropsychiatric diseases. However, the role of histone-modifying enzymes in the adult brain is still far from being understood. Here we use RNA sequencing to screen the levels of all known histone acetyltransferases (HATs) in the hippocampal CA1 region and find that K-acetyltransferase 2a (Kat2a)--a HAT that has not been studied for its role in memory function so far--shows highest expression. Mice that lack Kat2a show impaired hippocampal synaptic plasticity and long-term memory consolidation. We furthermore show that Kat2a regulates a highly interconnected hippocampal gene expression network linked to neuroactive receptor signaling via a mechanism that involves nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B). In conclusion, our data establish Kat2a as a novel and essential regulator of hippocampal memory consolidation. |*Gene Expression Regulation [MESH] |*Gene Regulatory Networks [MESH] |*Memory [MESH] |Animals [MESH] |CA1 Region, Hippocampal/enzymology [MESH] |Gene Expression Profiling [MESH] |Histone Acetyltransferases/genetics/*metabolism [MESH] |Mice [MESH]K-Lysine acetyltransferase 2a regulates a hippocampal gene expression (epmc).pdf DeepDyve Pubget Overpricing