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10.15252/embj.201488641 http://scihub22266oqcxt.onion/10.15252/embj.201488641 C4195771!4195771 !25069772     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25069772 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2014 ; 33 (18 ): 2040-56 Nephropedia Template TP {{tp|p=25069772 |t=2014. Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion |pdf=|usr=}}{{25069772 }} gab.com Text Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25069772 #FOAvip The microRNAs of the miR-200 family maintain the central characteristics of epithelia and inhibit tumor cell motility and invasiveness. Using the Ago-HITS-CLIP technology for transcriptome-wide identification of direct microRNA targets in living cells, along with extensive validation to verify the reliability of the approach, we have identified hundreds of miR-200a and miR-200b targets, providing insights into general features of miRNA target site selection. Gene ontology analysis revealed a predominant effect of miR-200 targets in widespread coordinate control of actin cytoskeleton dynamics. Functional characterization of the miR-200 targets indicates that they constitute subnetworks that underlie the ability of cancer cells to migrate and invade, including coordinate effects on Rho-ROCK signaling, invadopodia formation, MMP activity, and focal adhesions. Thus, the miR-200 family maintains the central characteristics of the epithelial phenotype by acting on numerous targets at multiple levels, encompassing both cytoskeletal effectors that control actin filament organization and dynamics, and upstream signals that locally regulate the cytoskeleton to maintain cell morphology and prevent cell migration. Twit Text FOAVip Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25069772 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25069772 #FOAvip English Wikipedia <ref>{{Cite pmid|25069772 }}</ref> Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion #MMPMID25069772 Bracken CP ; Li X ; Wright JA ; Lawrence DM ; Pillman KA ; Salmanidis M ; Anderson MA ; Dredge BK ; Gregory PA ; Tsykin A ; Neilsen C ; Thomson DW ; Bert AG ; Leerberg JM ; Yap AS ; Jensen KB ; Khew-Goodall Y ; Goodall GJ EMBO J 2014[Sep]; 33 (18 ): 2040-56 PMID25069772 show ga The microRNAs of the miR-200 family maintain the central characteristics of epithelia and inhibit tumor cell motility and invasiveness. Using the Ago-HITS-CLIP technology for transcriptome-wide identification of direct microRNA targets in living cells, along with extensive validation to verify the reliability of the approach, we have identified hundreds of miR-200a and miR-200b targets, providing insights into general features of miRNA target site selection. Gene ontology analysis revealed a predominant effect of miR-200 targets in widespread coordinate control of actin cytoskeleton dynamics. Functional characterization of the miR-200 targets indicates that they constitute subnetworks that underlie the ability of cancer cells to migrate and invade, including coordinate effects on Rho-ROCK signaling, invadopodia formation, MMP activity, and focal adhesions. Thus, the miR-200 family maintains the central characteristics of the epithelial phenotype by acting on numerous targets at multiple levels, encompassing both cytoskeletal effectors that control actin filament organization and dynamics, and upstream signals that locally regulate the cytoskeleton to maintain cell morphology and prevent cell migration. |*Cell Movement [MESH] |*Cell Proliferation [MESH] |*Gene Expression Regulation [MESH] |*Gene Regulatory Networks [MESH] |Cell Line [MESH] |Cytoskeleton/metabolism [MESH] |Epithelial Cells/*physiology [MESH] |Humans [MESH]Genome-wide identification of miR-200 targets reveals a regulatory net(epmc).pdf DeepDyve Pubget Overpricing