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10.1016/j.celrep.2014.08.070 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.08.070 C4194175!4194175!25284794     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25284794.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2014 ; 9 (1): 402-15 Nephropedia Template TP {{tp|p=25284794|t=2014. Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution |pdf=|usr=}}{{25284794}} gab.com Text Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25284794 #FOAvip Age-associated thymic involution results in diminished T cell output and function in aged individuals. However, molecular mediators contributing to the decline in thymic function during early thymic involution remain largely unknown. Here we present transcriptional profiling of purified thymic stromal subsets from mice 1, 3, and 6 months of age, spanning early thymic involution. The data implicate novel biological functions for a subset of thymic epithelial cells. The predominant transcriptional signature of early thymic involution is decreased expression of cell cycle associated genes and E2F3 transcriptional targets in thymic epithelial subsets. Also, expression of pro-inflammatory genes increases with age in thymic dendritic cells. Many genes previously implicated in late involution are already deregulated by 3 to 6 months of age. We provide these thymic stromal datasets, along with thymocyte datasets, in a readily searchable web-based platform, as a resource for investigations into thymocyte: stromal interactions and mechanisms of thymic involution. Twit Text FOAVip Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25284794 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25284794 #FOAvip English Wikipedia <ref>{{Cite pmid|25284794}}</ref> Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution #MMPMID25284794 Ki S; Park D; Selden HJ; Seita J; Chung H; Kim J; Iyer VR; Ehrlich LIR Cell Rep 2014[Oct]; 9 (1): 402-15 PMID25284794show ga Age-associated thymic involution results in diminished T cell output and function in aged individuals. However, molecular mediators contributing to the decline in thymic function during early thymic involution remain largely unknown. Here we present transcriptional profiling of purified thymic stromal subsets from mice 1, 3, and 6 months of age, spanning early thymic involution. The data implicate novel biological functions for a subset of thymic epithelial cells. The predominant transcriptional signature of early thymic involution is decreased expression of cell cycle associated genes and E2F3 transcriptional targets in thymic epithelial subsets. Also, expression of pro-inflammatory genes increases with age in thymic dendritic cells. Many genes previously implicated in late involution are already deregulated by 3 to 6 months of age. We provide these thymic stromal datasets, along with thymocyte datasets, in a readily searchable web-based platform, as a resource for investigations into thymocyte: stromal interactions and mechanisms of thymic involution. äGlobal transcriptional profiling reveals distinct functions of thymic (epmc).pdf DeepDyve Pubget Overpricing