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10.1016/j.celrep.2014.08.070 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.08.070 C4194175!4194175 !25284794     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25284794 &cmd=llinks): Failed to open stream: HTTP request failed! 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Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution |pdf=|usr=}}{{25284794 }} gab.com Text Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25284794 #FOAvip Age-associated thymic involution results in diminished T cell output and function in aged individuals. However, molecular mediators contributing to the decline in thymic function during early thymic involution remain largely unknown. Here, we present transcriptional profiling of purified thymic stromal subsets from mice 1, 3, and 6 months of age spanning early thymic involution. The data implicate unanticipated biological functions for a subset of thymic epithelial cells. The predominant transcriptional signature of early thymic involution is decreased expression of cell-cycle-associated genes and E2F3 transcriptional targets in thymic epithelial subsets. Also, expression of proinflammatory genes increases with age in thymic dendritic cells. Many genes previously implicated in late involution are already deregulated by 3-6 months of age. We provide these thymic stromal data sets, along with thymocyte data sets, in a readily searchable web-based platform, as a resource for investigations into thymocyte:stromal interactions and mechanisms of thymic involution. Twit Text FOAVip Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25284794 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25284794 #FOAvip English Wikipedia <ref>{{Cite pmid|25284794 }}</ref> Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution #MMPMID25284794 Ki S ; Park D ; Selden HJ ; Seita J ; Chung H ; Kim J ; Iyer VR ; Ehrlich LIR Cell Rep 2014[Oct]; 9 (1 ): 402-415 PMID25284794 show ga Age-associated thymic involution results in diminished T cell output and function in aged individuals. However, molecular mediators contributing to the decline in thymic function during early thymic involution remain largely unknown. Here, we present transcriptional profiling of purified thymic stromal subsets from mice 1, 3, and 6 months of age spanning early thymic involution. The data implicate unanticipated biological functions for a subset of thymic epithelial cells. The predominant transcriptional signature of early thymic involution is decreased expression of cell-cycle-associated genes and E2F3 transcriptional targets in thymic epithelial subsets. Also, expression of proinflammatory genes increases with age in thymic dendritic cells. Many genes previously implicated in late involution are already deregulated by 3-6 months of age. We provide these thymic stromal data sets, along with thymocyte data sets, in a readily searchable web-based platform, as a resource for investigations into thymocyte:stromal interactions and mechanisms of thymic involution. |Aging/*genetics [MESH] |Animals [MESH] |Humans [MESH] |Mice [MESH] |Stromal Cells/*metabolism [MESH] |Thymus Gland/*metabolism [MESH]Global transcriptional profiling reveals distinct functions of thymic (epmc).pdf DeepDyve Pubget Overpricing