Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.15252/embj.201386874 http://scihub22266oqcxt.onion/10.15252/embj.201386874 C4194125!4194125!24837709     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2014 ; 33 (12): 1365-82 Nephropedia Template TP {{tp|p=24837709|t=2014. Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer |pdf=|usr=}}{{24837709}} gab.com Text Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=24837709 #FOAvip Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. Hypoxia-inducible factor 1A (HIF1A) is a major regulator of this process, but its activation under normoxic conditions, termed pseudohypoxia, is not well documented. Here, using an integrative approach combining the first genome-wide mapping of chromatin binding for an endocytic adaptor, ARRB1, both in vitro and in vivo with gene expression profiling, we demonstrate that nuclear ARRB1 contributes to this metabolic shift in prostate cancer cells via regulation of HIF1A transcriptional activity under normoxic conditions through regulation of succinate dehydrogenase A (SDHA) and fumarate hydratase (FH) expression. ARRB1-induced pseudohypoxia may facilitate adaptation of cancer cells to growth in the harsh conditions that are frequently encountered within solid tumours. Our study is the first example of an endocytic adaptor protein regulating metabolic pathways. It implicates ARRB1 as a potential tumour promoter in prostate cancer and highlights the importance of metabolic alterations in prostate cancer. Twit Text FOAVip Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=24837709 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24837709 #FOAvip English Wikipedia <ref>{{Cite pmid|24837709}}</ref> Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer #MMPMID24837709 Zecchini V; Madhu B; Russell R; Pértega-Gomes N; Warren A; Gaude E; Borlido J; Stark R; Ireland-Zecchini H; Rao R; Scott H; Boren J; Massie C; Asim M; Brindle K; Griffiths J; Frezza C; Neal DE; Mills IG EMBO J 2014[Jun]; 33 (12): 1365-82 PMID24837709show ga Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. Hypoxia-inducible factor 1A (HIF1A) is a major regulator of this process, but its activation under normoxic conditions, termed pseudohypoxia, is not well documented. Here, using an integrative approach combining the first genome-wide mapping of chromatin binding for an endocytic adaptor, ARRB1, both in vitro and in vivo with gene expression profiling, we demonstrate that nuclear ARRB1 contributes to this metabolic shift in prostate cancer cells via regulation of HIF1A transcriptional activity under normoxic conditions through regulation of succinate dehydrogenase A (SDHA) and fumarate hydratase (FH) expression. ARRB1-induced pseudohypoxia may facilitate adaptation of cancer cells to growth in the harsh conditions that are frequently encountered within solid tumours. Our study is the first example of an endocytic adaptor protein regulating metabolic pathways. It implicates ARRB1 as a potential tumour promoter in prostate cancer and highlights the importance of metabolic alterations in prostate cancer. äNuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramm(epmc).pdf DeepDyve Pubget Overpricing