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10.15252/embj.201488598 http://scihub22266oqcxt.onion/10.15252/embj.201488598 C4194089!4194089!24825347     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2014 ; 33 (13): 1454-73 Nephropedia Template TP {{tp|p=24825347|t=2014. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer |pdf=|usr=}}{{24825347}} gab.com Text Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=24825347 #FOAvip Much of the mechanism by which Wnt signaling drives proliferation during oncogenesis is attributed to its regulation of the cell cycle. Here, we show how Wnt/?-catenin signaling directs another hallmark of tumorigenesis, namely Warburg metabolism. Using biochemical assays and fluorescence lifetime imaging microscopy (FLIM) to probe metabolism in vitro and in living tumors, we observe that interference with Wnt signaling in colon cancer cells reduces glycolytic metabolism and results in small, poorly perfused tumors. We identify pyruvate dehydrogenase kinase 1 (PDK1) as an important direct target within a larger gene program for metabolism. PDK1 inhibits pyruvate flux to mitochondrial respiration and a rescue of its expression in Wnt-inhibited cancer cells rescues glycolysis as well as vessel growth in the tumor microenvironment. Thus, we identify an important mechanism by which Wnt-driven Warburg metabolism directs the use of glucose for cancer cell proliferation and links it to vessel delivery of oxygen and nutrients. Twit Text FOAVip Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=24825347 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24825347 #FOAvip English Wikipedia <ref>{{Cite pmid|24825347}}</ref> Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer #MMPMID24825347 Pate KT; Stringari C; Sprowl-Tanio S; Wang K; TeSlaa T; Hoverter NP; McQuade MM; Garner C; Digman MA; Teitell MA; Edwards RA; Gratton E; Waterman ML EMBO J 2014[Jul]; 33 (13): 1454-73 PMID24825347show ga Much of the mechanism by which Wnt signaling drives proliferation during oncogenesis is attributed to its regulation of the cell cycle. Here, we show how Wnt/?-catenin signaling directs another hallmark of tumorigenesis, namely Warburg metabolism. Using biochemical assays and fluorescence lifetime imaging microscopy (FLIM) to probe metabolism in vitro and in living tumors, we observe that interference with Wnt signaling in colon cancer cells reduces glycolytic metabolism and results in small, poorly perfused tumors. We identify pyruvate dehydrogenase kinase 1 (PDK1) as an important direct target within a larger gene program for metabolism. PDK1 inhibits pyruvate flux to mitochondrial respiration and a rescue of its expression in Wnt-inhibited cancer cells rescues glycolysis as well as vessel growth in the tumor microenvironment. Thus, we identify an important mechanism by which Wnt-driven Warburg metabolism directs the use of glucose for cancer cell proliferation and links it to vessel delivery of oxygen and nutrients. äWnt signaling directs a metabolic program of glycolysis and angiogenes(epmc).pdf DeepDyve Pubget Overpricing