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The Good, the Bad, and the Ugly of interleukin-6 signaling #MMPMID24850773
Fuster JJ; Walsh K
EMBO J 2014[Jul]; 33 (13): 1425-7 PMID24850773show ga
Interleukin-6 (IL-6) is a pleiotropic cytokine with complex roles in inflammation and metabolic disease. While typically regarded as a pro-inflammatory cytokine, multiple studies in the last 20 years have generated conflicting data on the role of IL-6 in inflammation and metabolism. In a recent study in Nature Immunology, Brüning and collaborators demonstrate that IL-6 signaling in myeloid cells attenuates obesity-induced inflammation and insulin resistance by promoting macrophage alternative activation (Mauer et al, 2014). This study unveils a new and surprising anti-inflammatory action of IL-6 and further highlights the complex actions of this cytokine.