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10.1093/schbul/sbu059

http://scihub22266oqcxt.onion/10.1093/schbul/sbu059
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C4193723!4193723!24782561
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suck abstract from ncbi


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pmid24782561      Schizophr+Bull 2014 ; 40 (6): 1216-26
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  • Disrupted Modular Architecture of Cerebellum in Schizophrenia: A Graph Theoretic Analysis #MMPMID24782561
  • Kim DJ; Kent JS; Bolbecker AR; Sporns O; Cheng H; Newman SD; Puce A; O?Donnell BF; Hetrick WP
  • Schizophr Bull 2014[Nov]; 40 (6): 1216-26 PMID24782561show ga
  • Recent studies of schizophrenia have revealed cognitive and memory deficits that are accompanied by disruptions of neuronal connectivity in cortical and subcortical brain regions. More recently, alterations of topological organization of structural networks in schizophrenia are also being identified using graph theoretical analysis. However, the role of the cerebellum in this network structure remains largely unknown. In this study, global network measures obtained from diffusion tensor imaging were computed in the cerebella of 25 patients with schizophrenia and 36 healthy volunteers. While cerebellar global network characteristics were slightly altered in schizophrenia patients compared with healthy controls, the patients showed a retained small-world network organization. The modular architecture, however, was changed mainly in crus II. Furthermore, schizophrenia patients had reduced correlations between modularity and microstructural integrity, as measured by fractional anisotropy (FA) in lobules I?IV and X. Finally, FA alterations were significantly correlated with the Positive and Negative Syndrome Scale symptom scores in schizophrenia patients. Taken together, our data suggest that schizophrenia patients have altered network architecture in the cerebellum with reduced local microstructural connectivity and that cerebellar structural abnormalities are associated symptoms of the disorder.
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