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10.1182/blood-2014-04-569707 http://scihub22266oqcxt.onion/10.1182/blood-2014-04-569707 C4192753!4192753 !25085348     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25085348 &cmd=llinks): Failed to open stream: HTTP request failed! 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CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo |pdf=|usr=}}{{25085348 }} gab.com Text CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=25085348 #FOAvip Carcinoembryonic antigen-related cell adhesion molecule-2 (CEACAM2) is a cell-surface glycoprotein expressed on blood, epithelial, and vascular cells. CEACAM2 possesses adhesive and signaling properties mediated by immunoreceptor tyrosine-based inhibitory motifs. In this study, we demonstrate that CEACAM2 is expressed on the surface and in intracellular pools of platelets. Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcR?-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling. Cc2(-/-) platelets displayed enhanced GPVI and CLEC-2-selective ligands, collagen-related peptide (CRP), collagen, and rhodocytin (Rhod)-mediated platelet aggregation. They also exhibited increased adhesion on type I collagen, and hyperresponsive CRP and CLEC-2-induced ? and dense granule release compared with wild-type platelets. Furthermore, using intravital microscopy to ferric chloride (FeCl3)-injured mesenteric arterioles and laser-induced injury of cremaster muscle arterioles, we herein show that thrombi formed in Cc2(-/-) mice were larger and more stable than wild-type controls in vivo. Thus, CEACAM2 is a novel platelet immunoreceptor that acts as a negative regulator of platelet GPVI-collagen interactions and of ITAM receptor CLEC-2 pathways. Twit Text FOAVip CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=25085348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25085348 #FOAvip English Wikipedia <ref>{{Cite pmid|25085348 }}</ref> CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo #MMPMID25085348 Alshahrani MM ; Yang E ; Yip J ; Ghanem SS ; Abdallah SL ; deAngelis AM ; O'Malley CJ ; Moheimani F ; Najjar SM ; Jackson DE Blood 2014[Oct]; 124 (15 ): 2431-41 PMID25085348 show ga Carcinoembryonic antigen-related cell adhesion molecule-2 (CEACAM2) is a cell-surface glycoprotein expressed on blood, epithelial, and vascular cells. CEACAM2 possesses adhesive and signaling properties mediated by immunoreceptor tyrosine-based inhibitory motifs. In this study, we demonstrate that CEACAM2 is expressed on the surface and in intracellular pools of platelets. Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcR?-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling. Cc2(-/-) platelets displayed enhanced GPVI and CLEC-2-selective ligands, collagen-related peptide (CRP), collagen, and rhodocytin (Rhod)-mediated platelet aggregation. They also exhibited increased adhesion on type I collagen, and hyperresponsive CRP and CLEC-2-induced ? and dense granule release compared with wild-type platelets. Furthermore, using intravital microscopy to ferric chloride (FeCl3)-injured mesenteric arterioles and laser-induced injury of cremaster muscle arterioles, we herein show that thrombi formed in Cc2(-/-) mice were larger and more stable than wild-type controls in vivo. Thus, CEACAM2 is a novel platelet immunoreceptor that acts as a negative regulator of platelet GPVI-collagen interactions and of ITAM receptor CLEC-2 pathways. |*Signal Transduction/drug effects [MESH] |Animals [MESH] |Antigens, CD/*metabolism [MESH] |Blood Platelets/drug effects/metabolism/pathology [MESH] |Carrier Proteins/pharmacology [MESH] |Cell Adhesion Molecules/deficiency/*metabolism [MESH] |Cell Adhesion/drug effects [MESH] |Cell Membrane/metabolism [MESH] |Collagen Type I/metabolism [MESH] |Cytoplasmic Granules/drug effects/metabolism [MESH] |Hematopoiesis/drug effects [MESH] |Intracellular Signaling Peptides and Proteins/metabolism [MESH] |Intracellular Space/metabolism [MESH] |Lectins, C-Type/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Peptides/pharmacology [MESH] |Phospholipase C gamma/metabolism [MESH] |Phosphorylation/drug effects [MESH] |Platelet Membrane Glycoproteins/*metabolism [MESH] |Protein-Tyrosine Kinases/metabolism [MESH] |Regional Blood Flow/drug effects [MESH] |Syk Kinase [MESH] |Thrombosis/*metabolism/*pathology [MESH]CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathw(epmc).pdf DeepDyve Pubget Overpricing