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10.1113/jphysiol.2014.275735 http://scihub22266oqcxt.onion/10.1113/jphysiol.2014.275735 C4192698!4192698!25038239     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Physiol 2014 ; 592 (Pt 17): 3703-13 Nephropedia Template TP {{tp|p=25038239|t=2014. Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond |pdf=|usr=}}{{25038239}} gab.com Text Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond JO: J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25038239 #FOAvip Respiratory mitochondria undergo stochastic, intermittent bursts of superoxide production accompanied by transient depolarization of the mitochondrial membrane potential and reversible opening of the membrane permeability transition pore. These discrete events were named ?superoxide flashes? for the reactive oxygen species (ROS) signal involved, and ?mitochondrial flashes? (mitoflashes) for the entirety of the multifaceted and intertwined mitochondrial processes. In contrast to the flashless basal ROS production of ?homeostatic ROS? for redox regulation, bursting ROS production during mitoflashes may provide ?signalling ROS? at the organelle level, fulfilling distinctly different cell functions. Mounting evidence indicates that mitoflash frequency is richly regulated over a broad range, and represents a novel, universal, and ?digital? readout of mitochondrial functional status and of the mitochondrial stress response. An emerging view is that mitoflashes participate in vital processes including metabolism, cell differentiation, the stress response and ageing. These recent advances shed new light on the role of mitochondrial functional dynamics in health and disease. Twit Text FOAVip Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond ????J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25038239 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25038239 #FOAvip English Wikipedia <ref>{{Cite pmid|25038239}}</ref> Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond #MMPMID25038239 Hou T; Wang X; Ma Q; Cheng H J Physiol 2014[Sep]; 592 (Pt 17): 3703-13 PMID25038239show ga Respiratory mitochondria undergo stochastic, intermittent bursts of superoxide production accompanied by transient depolarization of the mitochondrial membrane potential and reversible opening of the membrane permeability transition pore. These discrete events were named ?superoxide flashes? for the reactive oxygen species (ROS) signal involved, and ?mitochondrial flashes? (mitoflashes) for the entirety of the multifaceted and intertwined mitochondrial processes. In contrast to the flashless basal ROS production of ?homeostatic ROS? for redox regulation, bursting ROS production during mitoflashes may provide ?signalling ROS? at the organelle level, fulfilling distinctly different cell functions. Mounting evidence indicates that mitoflash frequency is richly regulated over a broad range, and represents a novel, universal, and ?digital? readout of mitochondrial functional status and of the mitochondrial stress response. An emerging view is that mitoflashes participate in vital processes including metabolism, cell differentiation, the stress response and ageing. These recent advances shed new light on the role of mitochondrial functional dynamics in health and disease. äMitochondrial flashes: new insights into mitochondrial ROS signalling (epmc).pdf DeepDyve Pubget Overpricing