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10.1074/jbc.M114.558262

http://scihub22266oqcxt.onion/10.1074/jbc.M114.558262
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C4192514!4192514!25164814
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suck abstract from ncbi


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pmid25164814      J+Biol+Chem 2014 ; 289 (41): 28651-9
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  • Role of Rho GDP Dissociation Inhibitor ? in Control of Epithelial Sodium Channel (ENaC)-mediated Sodium Reabsorption* #MMPMID25164814
  • Pavlov TS; Levchenko V; Staruschenko A
  • J Biol Chem 2014[Oct]; 289 (41): 28651-9 PMID25164814show ga
  • Background: RhoGDI? regulates activity of Rho family small GTPases, which are recognized as important modulators of ENaC.Results: RhoGDI? modulates Rac1 activity and partially participates in the effects of EGF on ENaC in the cortical collecting ducts.Conclusion: RhoGDI? controls ENaC expression and activity via Rac1.Significance: A novel mechanism for RhoGDI?-dependent regulation of ENaC is presented.
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