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10.1038/nm.3665 http://scihub22266oqcxt.onion/10.1038/nm.3665 C4192073!4192073!25194570     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2014 ; 20 (10): 1130-7 Nephropedia Template TP {{tp|p=25194570|t=2014. N-Me, a long range oncogenic enhancer in T-cell acute lymphoblastic leukemia |pdf=|usr=}}{{25194570}} gab.com Text N-Me, a long range oncogenic enhancer in T-cell acute lymphoblastic leukemia JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25194570 #FOAvip Efforts to identify and annotate cancer driver genetic lesions have been almost exclusively focused on the analysis of protein coding genes. Here we identify a new long-range acting MYC enhancer controlled by NOTCH1, targeted by recurrent chromosomal duplications in human T-cell acute lymphoblastic leukemia (T-ALL). This highly conserved regulatory element, hereby named N-Me for NOTCH MYC enhancer, is located within a broad super-enhancer region +1.47 Mb from the MYC transcription initiating site, interacts with the MYC proximal promoter and induces orientation-independent MYC expression in reporter assays. Moreover, analysis of N-Me knockout mice demonstrates a selective and essential role of this regulatory element during thymocyte development and in NOTCH1-induced T-ALL. Altogether, these results identify N-Me as a long range oncogenic enhancer directly implicated in the pathogenesis of human leukemia and highlight the fundamental importance of the NOTCH1-MYC regulatory axis in T-cell transformation and as therapeutic target in T-ALL. Twit Text FOAVip N-Me, a long range oncogenic enhancer in T-cell acute lymphoblastic leukemia ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25194570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25194570 #FOAvip English Wikipedia <ref>{{Cite pmid|25194570}}</ref> N-Me, a long range oncogenic enhancer in T-cell acute lymphoblastic leukemia #MMPMID25194570 Herranz D; Ambesi-Impiombato A; Palomero T; Schnell SA; Belver L; Wendorff AA; Xu L; Castillo-Martin M; Llobet-Navás D; Cardo CC; Clappier E; Soulier J; Ferrando AA Nat Med 2014[Oct]; 20 (10): 1130-7 PMID25194570show ga Efforts to identify and annotate cancer driver genetic lesions have been almost exclusively focused on the analysis of protein coding genes. Here we identify a new long-range acting MYC enhancer controlled by NOTCH1, targeted by recurrent chromosomal duplications in human T-cell acute lymphoblastic leukemia (T-ALL). This highly conserved regulatory element, hereby named N-Me for NOTCH MYC enhancer, is located within a broad super-enhancer region +1.47 Mb from the MYC transcription initiating site, interacts with the MYC proximal promoter and induces orientation-independent MYC expression in reporter assays. Moreover, analysis of N-Me knockout mice demonstrates a selective and essential role of this regulatory element during thymocyte development and in NOTCH1-induced T-ALL. Altogether, these results identify N-Me as a long range oncogenic enhancer directly implicated in the pathogenesis of human leukemia and highlight the fundamental importance of the NOTCH1-MYC regulatory axis in T-cell transformation and as therapeutic target in T-ALL. äN-Me, a long range oncogenic enhancer in T-cell acute lymphoblastic le(epmc).pdf DeepDyve Pubget Overpricing