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10.1093/nar/gku852 http://scihub22266oqcxt.onion/10.1093/nar/gku852 C4191419!4191419 !25249625     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25249625 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2014 ; 42 (18 ): 11433-46 Nephropedia Template TP {{tp|p=25249625 |t=2014. SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression |pdf=|usr=}}{{25249625 }} gab.com Text SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=25249625 #FOAvip Polycomb group (PcG) complexes regulate cellular identity through epigenetic programming of chromatin. Here, we show that SSX2, a germline-specific protein ectopically expressed in melanoma and other types of human cancers, is a chromatin-associated protein that antagonizes BMI1 and EZH2 PcG body formation and derepresses PcG target genes. SSX2 further negatively regulates the level of the PcG-associated histone mark H3K27me3 in melanoma cells, and there is a clear inverse correlation between SSX2/3 expression and H3K27me3 in spermatogenesis. However, SSX2 does not affect the overall composition and stability of PcG complexes, and there is no direct concordance between SSX2 and BMI1/H3K27me3 presence at regulated genes. This suggests that SSX2 antagonizes PcG function through an indirect mechanism, such as modulation of chromatin structure. SSX2 binds double-stranded DNA in a sequence non-specific manner in agreement with the observed widespread association with chromatin. Our results implicate SSX2 in regulation of chromatin structure and function. Twit Text FOAVip SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=25249625 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25249625 #FOAvip English Wikipedia <ref>{{Cite pmid|25249625 }}</ref> SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression #MMPMID25249625 Gjerstorff MF ; Relster MM ; Greve KB ; Moeller JB ; Elias D ; Lindgreen JN ; Schmidt S ; Mollenhauer J ; Voldborg B ; Pedersen CB ; Brückmann NH ; Møllegaard NE ; Ditzel HJ Nucleic Acids Res 2014[Oct]; 42 (18 ): 11433-46 PMID25249625 show ga Polycomb group (PcG) complexes regulate cellular identity through epigenetic programming of chromatin. Here, we show that SSX2, a germline-specific protein ectopically expressed in melanoma and other types of human cancers, is a chromatin-associated protein that antagonizes BMI1 and EZH2 PcG body formation and derepresses PcG target genes. SSX2 further negatively regulates the level of the PcG-associated histone mark H3K27me3 in melanoma cells, and there is a clear inverse correlation between SSX2/3 expression and H3K27me3 in spermatogenesis. However, SSX2 does not affect the overall composition and stability of PcG complexes, and there is no direct concordance between SSX2 and BMI1/H3K27me3 presence at regulated genes. This suggests that SSX2 antagonizes PcG function through an indirect mechanism, such as modulation of chromatin structure. SSX2 binds double-stranded DNA in a sequence non-specific manner in agreement with the observed widespread association with chromatin. Our results implicate SSX2 in regulation of chromatin structure and function. |*Gene Expression Regulation, Neoplastic [MESH] |Cell Line, Tumor [MESH] |Cell Nucleus/metabolism [MESH] |Chromatin/metabolism [MESH] |DNA/chemistry/metabolism [MESH] |Enhancer of Zeste Homolog 2 Protein [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Melanoma/genetics/metabolism [MESH] |Neoplasm Proteins/*metabolism/physiology [MESH] |Polycomb Repressive Complex 1/antagonists & inhibitors/chemistry/metabolism [MESH] |Polycomb Repressive Complex 2/antagonists & inhibitors/chemistry/metabolism [MESH] |Polycomb-Group Proteins/*antagonists & inhibitors [MESH] |Repressor Proteins/*metabolism/physiology [MESH]SSX2 is a novel DNA-binding protein that antagonizes polycomb group bo(epmc).pdf DeepDyve Pubget Overpricing