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10.1016/j.bpj.2014.07.061 http://scihub22266oqcxt.onion/10.1016/j.bpj.2014.07.061 C4190650!4190650 !25296304     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25296304 &cmd=llinks): Failed to open stream: HTTP request failed! 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Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility |pdf=|usr=}}{{25296304 }} gab.com Text Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=25296304 #FOAvip Neisseria gonorrheae bacteria are the causative agent of the second most common sexually transmitted infection in the world. The bacteria move on a surface by means of twitching motility. Their movement is mediated by multiple long and flexible filaments, called type IV pili, that extend from the cell body, attach to the surface, and retract, thus generating a pulling force. Moving cells also use pili to aggregate and form microcolonies. However, the mechanism by which the pili surrounding the cell body work together to propel bacteria remains unclear. Understanding this process will help describe the motility of N. gonorrheae bacteria, and thus the dissemination of the disease which they cause. In this article we track individual twitching cells and observe that their trajectories consist of alternating moving and pausing intervals, while the cell body is preferably oriented with its wide side toward the direction of motion. Based on these data, we propose a model for the collective pili operation of N. gonorrheae bacteria that explains the experimentally observed behavior. Individual pili function independently but can lead to coordinated motion or pausing via the force balance. The geometry of the cell defines its orientation during motion. We show that by changing pili substrate interactions, the motility pattern can be altered in a predictable way. Although the model proposed is tangibly simple, it still has sufficient robustness to incorporate further advanced pili features and various cell geometries to describe other bacteria that employ pili to move on surfaces. Twit Text FOAVip Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=25296304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25296304 #FOAvip English Wikipedia <ref>{{Cite pmid|25296304 }}</ref> Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility #MMPMID25296304 Zaburdaev V ; Biais N ; Schmiedeberg M ; Eriksson J ; Jonsson AB ; Sheetz MP ; Weitz DA Biophys J 2014[Oct]; 107 (7 ): 1523-31 PMID25296304 show ga Neisseria gonorrheae bacteria are the causative agent of the second most common sexually transmitted infection in the world. The bacteria move on a surface by means of twitching motility. Their movement is mediated by multiple long and flexible filaments, called type IV pili, that extend from the cell body, attach to the surface, and retract, thus generating a pulling force. Moving cells also use pili to aggregate and form microcolonies. However, the mechanism by which the pili surrounding the cell body work together to propel bacteria remains unclear. Understanding this process will help describe the motility of N. gonorrheae bacteria, and thus the dissemination of the disease which they cause. In this article we track individual twitching cells and observe that their trajectories consist of alternating moving and pausing intervals, while the cell body is preferably oriented with its wide side toward the direction of motion. Based on these data, we propose a model for the collective pili operation of N. gonorrheae bacteria that explains the experimentally observed behavior. Individual pili function independently but can lead to coordinated motion or pausing via the force balance. The geometry of the cell defines its orientation during motion. We show that by changing pili substrate interactions, the motility pattern can be altered in a predictable way. Although the model proposed is tangibly simple, it still has sufficient robustness to incorporate further advanced pili features and various cell geometries to describe other bacteria that employ pili to move on surfaces. |*Movement [MESH] |Biomechanical Phenomena [MESH] |Fimbriae, Bacterial/metabolism [MESH] |Models, Biological [MESH] |Neisseria gonorrhoeae/*cytology [MESH]Uncovering the mechanism of trapping and cell orientation during Neiss(epmc).pdf DeepDyve Pubget Overpricing