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10.1016/j.ajpath.2014.06.021 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2014.06.021 C4188867!4188867!25108226     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 2014 ; 184 (10): 2709-20 Nephropedia Template TP {{tp|p=25108226|t=2014. Peroxisome Proliferator?Activated Receptor ? Protects Capillary Pericytes in the Retina |pdf=|usr=}}{{25108226}} gab.com Text Peroxisome Proliferator Activated Receptor Protects Capillary Pericytes in the Retina JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25108226 #FOAvip Pericyte degeneration is an early event in diabetic retinopathy and plays an important role in progression of diabetic retinopathy. Clinical studies have shown that fenofibrate, a peroxisome proliferator?activated receptor ? (PPAR?) agonist, has robust therapeutic effects on diabetic retinopathy in type 2 diabetic patients. We evaluated the protective effect of PPAR? against pericyte loss in diabetic retinopathy. In streptozotocin-induced diabetic mice, fenofibrate treatment significantly ameliorated retinal acellular capillary formation and pericyte loss. In contrast, PPAR??/? mice with diabetes developed more severe retinal acellular capillary formation and pericyte dropout, compared with diabetic wild-type mice. Furthermore, PPAR? knockout abolished the protective effect of fenofibrate against diabetes-induced retinal pericyte loss. In cultured primary human retinal capillary pericytes, activation and expression of PPAR? both significantly reduced oxidative stress?induced apoptosis, decreased reactive oxygen species production, and down-regulated NAD(P)H oxidase 4 expression through blockade of NF-?B activation. Furthermore, activation and expression of PPAR? both attenuated the oxidant-induced suppression of mitochondrial O2 consumption in human retinal capillary pericytes. Primary retinal pericytes from PPAR??/? mice displayed more apoptosis, compared with those from wild-type mice under the same oxidative stress. These findings identified a protective effect of PPAR? on retinal pericytes, a novel function of endogenous PPAR? in the retina. Twit Text FOAVip Peroxisome Proliferator Activated Receptor Protects Capillary Pericytes in the Retina ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25108226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25108226 #FOAvip English Wikipedia <ref>{{Cite pmid|25108226}}</ref> Peroxisome Proliferator?Activated Receptor ? Protects Capillary Pericytes in the Retina #MMPMID25108226 Ding L; Cheng R; Hu Y; Takahashi Y; Jenkins AJ; Keech AC; Humphries KM; Gu X; Elliott MH; Xia X; Ma Jx Am J Pathol 2014[Oct]; 184 (10): 2709-20 PMID25108226show ga Pericyte degeneration is an early event in diabetic retinopathy and plays an important role in progression of diabetic retinopathy. Clinical studies have shown that fenofibrate, a peroxisome proliferator?activated receptor ? (PPAR?) agonist, has robust therapeutic effects on diabetic retinopathy in type 2 diabetic patients. We evaluated the protective effect of PPAR? against pericyte loss in diabetic retinopathy. In streptozotocin-induced diabetic mice, fenofibrate treatment significantly ameliorated retinal acellular capillary formation and pericyte loss. In contrast, PPAR??/? mice with diabetes developed more severe retinal acellular capillary formation and pericyte dropout, compared with diabetic wild-type mice. Furthermore, PPAR? knockout abolished the protective effect of fenofibrate against diabetes-induced retinal pericyte loss. In cultured primary human retinal capillary pericytes, activation and expression of PPAR? both significantly reduced oxidative stress?induced apoptosis, decreased reactive oxygen species production, and down-regulated NAD(P)H oxidase 4 expression through blockade of NF-?B activation. Furthermore, activation and expression of PPAR? both attenuated the oxidant-induced suppression of mitochondrial O2 consumption in human retinal capillary pericytes. Primary retinal pericytes from PPAR??/? mice displayed more apoptosis, compared with those from wild-type mice under the same oxidative stress. These findings identified a protective effect of PPAR? on retinal pericytes, a novel function of endogenous PPAR? in the retina. äPeroxisome Proliferator?Activated Receptor ? Protects Capillary Pericy(epmc).pdf DeepDyve Pubget Overpricing