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2014 ; 25
(3
): 385-9
Nephropedia Template TP
gab.com Text
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English Wikipedia
Effectiveness of the ribavirin in treatment of hantavirus infections in the
Americas and Eurasia: a meta-analysis
#MMPMID25674609
Moreli ML
; Marques-Silva AC
; Pimentel VA
; da Costa VG
Virusdisease
2014[]; 25
(3
): 385-9
PMID25674609
show ga
Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome
(HPS) are transmitted to humans through infection with the old- and new-world
hantaviruses, respectively. Together these diseases affect tens of thousands of
people every year, and no specific treatment is available. To investigate whether
ribavirin treatment for hantaviruses infections decreases disease severity, we
conducted a meta-analysis involving human and animal studies. After defining the
research protocol and criteria for inclusion/exclusion, we identified seven
studies. We found that in groups with HPS who were treated with ribavirin, there
was no significant reduction in mortality (RR 0.99, 95 % CI 0.60-1.61,
I(2) = 0 %). On the other hand, for animal group with HPS-like disease, there was
significant increase in survival (RR 0.05, 95 % CI 0.01-0.34, I(2) = 0 %). For
animal group infected with the old-world hantaviruses, treated with ribavirin,
there was a statistically significant increase in survival (RR 0.56, 95 % CI
0.42-0.76, I(2) = 64 %). Similarly, for humans with HFRS treated, there was
increase in survival (RR 0.28, 95 % CI 0.08-1), although only a study exist. Our
meta-analysis provides data that should be interpreted with caution, partly due
to the limited number of studies available. Additionally, the results of the
application of ribavirin in the population with HPS could not be determined,
particularly in patients in the end stage of this disease.