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10.1128/AAC.02765-14 http://scihub22266oqcxt.onion/10.1128/AAC.02765-14 C4187982!4187982!25092707     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antimicrob+Agents+Chemother 2014 ; 58 (10): 6044-55 Nephropedia Template TP {{tp|p=25092707|t=2014. Nitro/Nitrosyl-Ruthenium Complexes Are Potent and Selective Anti-Trypanosoma cruzi Agents Causing Autophagy and Necrotic Parasite Death |pdf=|usr=}}{{25092707}} gab.com Text Nitro/Nitrosyl-Ruthenium Complexes Are Potent and Selective Anti-Trypanosoma cruzi Agents Causing Autophagy and Necrotic Parasite Death JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25092707 #FOAvip cis-[RuCl(NO2)(dppb)(5,5?-mebipy)] (complex 1), cis-[Ru(NO2)2(dppb)(5,5?-mebipy)] (complex 2), ct-[RuCl(NO)(dppb)(5,5?-mebipy)](PF6)2 (complex 3), and cc-[RuCl(NO)(dppb)(5,5?-mebipy)](PF6)2 (complex 4), where 5,5?-mebipy is 5,5?-dimethyl-2,2?-bipyridine and dppb is 1,4-bis(diphenylphosphino)butane, were synthesized and characterized. The structure of complex 2 was determined by X-ray crystallography. These complexes exhibited a higher anti-Trypanosoma cruzi activity than benznidazole, the current antiparasitic drug. Complex 3 was the most potent, displaying a 50% effective concentration (EC50) of 2.1 ± 0.6 ?M against trypomastigotes and a 50% inhibitory concentration (IC50) of 1.3 ± 0.2 ?M against amastigotes, while it displayed a 50% cytotoxic concentration (CC50) of 51.4 ± 0.2 ?M in macrophages. It was observed that the nitrosyl complex 3, but not its analog lacking the nitrosyl group, releases nitric oxide into parasite cells. This release has a diminished effect on the trypanosomal protease cruzain but induces substantial parasite autophagy, which is followed by a series of irreversible morphological impairments to the parasites and finally results in cell death by necrosis. In infected mice, orally administered complex 3 (five times at a dose of 75 ?mol/kg of body weight) reduced blood parasitemia and increased the survival rate of the mice. Combination index analysis of complex 3 indicated that its in vitro activity against trypomastigotes is synergic with benznidazole. In addition, drug combination enhanced efficacy in infected mice, suggesting that ruthenium-nitrosyl complexes are potential constituents for drug combinations. Twit Text FOAVip Nitro/Nitrosyl-Ruthenium Complexes Are Potent and Selective Anti-Trypanosoma cruzi Agents Causing Autophagy and Necrotic Parasite Death ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25092707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25092707 #FOAvip English Wikipedia <ref>{{Cite pmid|25092707}}</ref> Nitro/Nitrosyl-Ruthenium Complexes Are Potent and Selective Anti-Trypanosoma cruzi Agents Causing Autophagy and Necrotic Parasite Death #MMPMID25092707 Bastos TM; Barbosa MIF; da Silva MM; da C. Júnior JW; Meira CS; Guimaraes ET; Ellena J; Moreira DRM; Batista AA; Soares MBP Antimicrob Agents Chemother 2014[Oct]; 58 (10): 6044-55 PMID25092707show ga cis-[RuCl(NO2)(dppb)(5,5?-mebipy)] (complex 1), cis-[Ru(NO2)2(dppb)(5,5?-mebipy)] (complex 2), ct-[RuCl(NO)(dppb)(5,5?-mebipy)](PF6)2 (complex 3), and cc-[RuCl(NO)(dppb)(5,5?-mebipy)](PF6)2 (complex 4), where 5,5?-mebipy is 5,5?-dimethyl-2,2?-bipyridine and dppb is 1,4-bis(diphenylphosphino)butane, were synthesized and characterized. The structure of complex 2 was determined by X-ray crystallography. These complexes exhibited a higher anti-Trypanosoma cruzi activity than benznidazole, the current antiparasitic drug. Complex 3 was the most potent, displaying a 50% effective concentration (EC50) of 2.1 ± 0.6 ?M against trypomastigotes and a 50% inhibitory concentration (IC50) of 1.3 ± 0.2 ?M against amastigotes, while it displayed a 50% cytotoxic concentration (CC50) of 51.4 ± 0.2 ?M in macrophages. It was observed that the nitrosyl complex 3, but not its analog lacking the nitrosyl group, releases nitric oxide into parasite cells. This release has a diminished effect on the trypanosomal protease cruzain but induces substantial parasite autophagy, which is followed by a series of irreversible morphological impairments to the parasites and finally results in cell death by necrosis. In infected mice, orally administered complex 3 (five times at a dose of 75 ?mol/kg of body weight) reduced blood parasitemia and increased the survival rate of the mice. Combination index analysis of complex 3 indicated that its in vitro activity against trypomastigotes is synergic with benznidazole. In addition, drug combination enhanced efficacy in infected mice, suggesting that ruthenium-nitrosyl complexes are potential constituents for drug combinations. äNitro/Nitrosyl-Ruthenium Complexes Are Potent and Selective Anti-Trypa(epmc).pdf DeepDyve Pubget Overpricing