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10.1128/AAC.03355-14

http://scihub22266oqcxt.onion/10.1128/AAC.03355-14
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suck abstract from ncbi


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pmid25092693
      Antimicrob+Agents+Chemother 2014 ; 58 (10 ): 6302-5
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  • NDM-12, a novel New Delhi metallo-?-lactamase variant from a carbapenem-resistant Escherichia coli clinical isolate in Nepal #MMPMID25092693
  • Tada T ; Shrestha B ; Miyoshi-Akiyama T ; Shimada K ; Ohara H ; Kirikae T ; Pokhrel BM
  • Antimicrob Agents Chemother 2014[Oct]; 58 (10 ): 6302-5 PMID25092693 show ga
  • A novel New Delhi metallo-?-lactamase variant, NDM-12, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from a urine sample from a patient in Nepal. NDM-12 differed from NDM-1 by two amino acid substitutions (M154L and G222D). The enzymatic activities of NDM-12 against ?-lactams were similar to those of NDM-1, although NDM-12 showed lower kcat/Km ratios for all ?-lactams tested except doripenem. The blaNDM-12 gene was located in a plasmid of 160 kb.
  • |Anti-Bacterial Agents/*pharmacology [MESH]
  • |Carbapenems/*pharmacology [MESH]
  • |Escherichia coli/*drug effects/*enzymology [MESH]
  • |Microbial Sensitivity Tests [MESH]
  • |Nepal [MESH]


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