Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25278572
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Microbiol+Rev
2014 ; 27
(4
): 691-726
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Pathogens penetrating the central nervous system: infection pathways and the
cellular and molecular mechanisms of invasion
#MMPMID25278572
Dando SJ
; Mackay-Sim A
; Norton R
; Currie BJ
; St John JA
; Ekberg JA
; Batzloff M
; Ulett GC
; Beacham IR
Clin Microbiol Rev
2014[Oct]; 27
(4
): 691-726
PMID25278572
show ga
The brain is well protected against microbial invasion by cellular barriers, such
as the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier
(BCSFB). In addition, cells within the central nervous system (CNS) are capable
of producing an immune response against invading pathogens. Nonetheless, a range
of pathogenic microbes make their way to the CNS, and the resulting infections
can cause significant morbidity and mortality. Bacteria, amoebae, fungi, and
viruses are capable of CNS invasion, with the latter using axonal transport as a
common route of infection. In this review, we compare the mechanisms by which
bacterial pathogens reach the CNS and infect the brain. In particular, we focus
on recent data regarding mechanisms of bacterial translocation from the nasal
mucosa to the brain, which represents a little explored pathway of bacterial
invasion but has been proposed as being particularly important in explaining how
infection with Burkholderia pseudomallei can result in melioidosis
encephalomyelitis.