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10.1002/cbic.201402258 http://scihub22266oqcxt.onion/10.1002/cbic.201402258 C4187115!4187115 !25125376     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25125376 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Chembiochem 2014 ; 15 (14 ): 2125-31 Nephropedia Template TP {{tp|p=25125376 |t=2014. Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action |pdf=|usr=}}{{25125376 }} gab.com Text Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action JO: Chembiochem http://www.kidney.de/pget.php?&tw=1&pmid=25125376 #FOAvip Access to lead compounds with defined molecular targets continues to be a barrier to the translation of natural product resources. As a solution, we developed a system that uses discrete, recombinant proteins as the vehicles for natural product isolation. Here, we describe the use of this functional chromatographic method to identify natural products that bind to the AAA+ chaperone, p97, a promising cancer target. Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1-hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators. Excitingly, each of these molecules displayed a unique mechanism of p97 modulation. This discovery provides strong support for the application of functional chromatography to the discovery of protein modulators that would likely escape traditional high-throughput or phenotypic screening platforms. Twit Text FOAVip Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action ????Chembiochem http://www.kidney.de/pget.php?&tw=1&pmid=25125376 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25125376 #FOAvip English Wikipedia <ref>{{Cite pmid|25125376 }}</ref> Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action #MMPMID25125376 Kang MJ ; Wu T ; Wijeratne EM ; Lau EC ; Mason DJ ; Mesa C ; Tillotson J ; Zhang DD ; Gunatilaka AA ; La Clair JJ ; Chapman E Chembiochem 2014[Sep]; 15 (14 ): 2125-31 PMID25125376 show ga Access to lead compounds with defined molecular targets continues to be a barrier to the translation of natural product resources. As a solution, we developed a system that uses discrete, recombinant proteins as the vehicles for natural product isolation. Here, we describe the use of this functional chromatographic method to identify natural products that bind to the AAA+ chaperone, p97, a promising cancer target. Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1-hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators. Excitingly, each of these molecules displayed a unique mechanism of p97 modulation. This discovery provides strong support for the application of functional chromatography to the discovery of protein modulators that would likely escape traditional high-throughput or phenotypic screening platforms. |Adenosine Triphosphatases/*metabolism [MESH] |Alkaloids/chemistry/isolation & purification/pharmacology [MESH] |Biological Products/chemistry/isolation & purification/*pharmacology [MESH] |Chromatography/methods [MESH] |Drug Discovery/methods [MESH] |Fungi/chemistry [MESH] |Humans [MESH] |Naphthoquinones/chemistry/isolation & purification/pharmacology [MESH] |Nuclear Proteins/*metabolism [MESH]Functional chromatography reveals three natural products that target t(epmc).pdf DeepDyve Pubget Overpricing