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10.1016/j.jaci.2014.05.048 http://scihub22266oqcxt.onion/10.1016/j.jaci.2014.05.048 C4186911!4186911 !25131691     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25131691 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Allergy+Clin+Immunol 2014 ; 134 (4 ): 781-791.e1 Nephropedia Template TP {{tp|p=25131691 |t=2014. Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis |pdf=|usr=}}{{25131691 }} gab.com Text Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25131691 #FOAvip I review how diverse inherited and acquired abnormalities in epidermal structural and enzymatic proteins converge to produce defective permeability barrier function and antimicrobial defense in patients with atopic dermatitis (AD). Although best known are mutations in filaggrin (FLG), mutations in other member of the fused S-100 family of proteins (ie, hornerin [hrn] and filaggrin 2 [flg-2]); the cornified envelope precursor (ie, SPRR3); mattrin, which is encoded by TMEM79 and regulates the assembly of lamellar bodies; SPINK5, which encodes the serine protease inhibitor lymphoepithelial Kazal-type trypsin inhibitor type 1; and the fatty acid transporter fatty acid transport protein 4 have all been linked to AD. Yet these abnormalities often only predispose to AD; additional acquired stressors that further compromise barrier function, such as psychological stress, low ambient humidity, or high-pH surfactants, often are required to trigger disease. T(H)2 cytokines can also compromise barrier function by downregulating expression of multiple epidermal structural proteins, lipid synthetic enzymes, and antimicrobial peptides. All of these inherited and acquired abnormalities converge on the lamellar body secretory system, producing abnormalities in lipid composition, secretion, and/or extracellular lamellar membrane organization, as well as antimicrobial defense. Finally, I briefly review therapeutic options that address this new pathogenic paradigm. Twit Text FOAVip Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25131691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25131691 #FOAvip English Wikipedia <ref>{{Cite pmid|25131691 }}</ref> Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis #MMPMID25131691 Elias PM ; Wakefield JS J Allergy Clin Immunol 2014[Oct]; 134 (4 ): 781-791.e1 PMID25131691 show ga I review how diverse inherited and acquired abnormalities in epidermal structural and enzymatic proteins converge to produce defective permeability barrier function and antimicrobial defense in patients with atopic dermatitis (AD). Although best known are mutations in filaggrin (FLG), mutations in other member of the fused S-100 family of proteins (ie, hornerin [hrn] and filaggrin 2 [flg-2]); the cornified envelope precursor (ie, SPRR3); mattrin, which is encoded by TMEM79 and regulates the assembly of lamellar bodies; SPINK5, which encodes the serine protease inhibitor lymphoepithelial Kazal-type trypsin inhibitor type 1; and the fatty acid transporter fatty acid transport protein 4 have all been linked to AD. Yet these abnormalities often only predispose to AD; additional acquired stressors that further compromise barrier function, such as psychological stress, low ambient humidity, or high-pH surfactants, often are required to trigger disease. T(H)2 cytokines can also compromise barrier function by downregulating expression of multiple epidermal structural proteins, lipid synthetic enzymes, and antimicrobial peptides. All of these inherited and acquired abnormalities converge on the lamellar body secretory system, producing abnormalities in lipid composition, secretion, and/or extracellular lamellar membrane organization, as well as antimicrobial defense. Finally, I briefly review therapeutic options that address this new pathogenic paradigm. |Animals [MESH] |Bodily Secretions/physiology [MESH] |Dermatitis, Atopic/etiology/*physiopathology [MESH] |Fatty Acid Transport Proteins/genetics/*metabolism [MESH] |Filaggrin Proteins [MESH] |Gene-Environment Interaction [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Inclusion Bodies/genetics/immunology [MESH] |Intermediate Filament Proteins/genetics/*metabolism [MESH] |Lipid Metabolism/genetics [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Proteinase Inhibitory Proteins, Secretory/genetics/*metabolism [MESH] |Proteolysis [MESH] |Serine Peptidase Inhibitor Kazal-Type 5 [MESH]Mechanisms of abnormal lamellar body secretion and the dysfunctional s(epmc).pdf DeepDyve Pubget Overpricing