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10.2215/CJN.10441013 http://scihub22266oqcxt.onion/10.2215/CJN.10441013 C4186521!4186521 !25104273     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25104273 &cmd=llinks): Failed to open stream: HTTP request failed! 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Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial |pdf=|usr=}}{{25104273 }} gab.com Text Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial JO: Clin J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25104273 #FOAvip BACKGROUND AND OBJECTIVES: Kidney function gradually decreases with age, and myocardial infarction accelerates this deterioration. Omega-3 (n-3) fatty acids may slow down the decline of kidney function. The effect of marine and plant-derived n-3 fatty acids on kidney function in patients after myocardial infarction was examined. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In the Alpha Omega Trial, 2344 patients with history of myocardial infarction ages 60-80 years old (81% men) were randomized to one of four trial margarines. The patients received an additional targeted amount of 400 mg/d eicosapentaenoic acid and docosahexaenoic acid, 2 g/d ?-linolenic acid, eicosapentaenoic acid-docosahexaenoic acid plus ?-linolenic acid, or placebo for 40 months. Serum cystatin C and serum creatinine were assessed at baseline and after 40 months. Creatinine-cystatin C-based GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation. RESULTS: Patients consumed 19.9 g margarine/d, providing an additional 239 mg/d eicosapentaenoic acid with 159 mg/d docosahexaenoic acid, 1.99 g/d ?-linolenic acid, or both in the active treatment groups. After 40 months, compared with baseline, mean (±SD) creatinine-cystatin C-based GFR was -6.9 (±12.6), -4.8 (±13.4), -6.2 (±12.8), and -6.0 (±13.0) ml/min per 1.73 m(2) in the placebo, eicosapentaenoic acid-docosahexaenoic acid, ?-linolenic acid, and eicosapentaenoic acid-docosahexaenoic acid plus ?-linolenic acid groups, respectively. After 40 months, in patients receiving eicosapentaenoic acid-docosahexaenoic acid compared with placebo, the decline in creatinine-cystatin C-based GFR was 2.1 less (95% confidence interval, 0.6 to 3.6; P<0.01) ml/min per 1.73 m(2); other comparisons were not statistical significant. Odds ratios (95% confidence intervals) of incident CKD (<60 ml/min per 1.73 m(2)) and rapid decline of kidney function (?3 ml/min per year) for eicosapentaenoic acid-docosahexaenoic acid compared with placebo were 0.83 (0.58 to 1.18) and 0.85 (0.67 to 1.08), respectively. CONCLUSIONS: Long-term supplementation with 400 mg/d eicosapentaenoic acid-docosahexaenoic acid provides a small beneficial effect on kidney function in patients with a history of myocardial infarction. Twit Text FOAVip Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial ????Clin J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25104273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25104273 #FOAvip English Wikipedia <ref>{{Cite pmid|25104273 }}</ref> Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial #MMPMID25104273 Hoogeveen EK ; Geleijnse JM ; Kromhout D ; Stijnen T ; Gemen EF ; Kusters R ; Giltay EJ Clin J Am Soc Nephrol 2014[Oct]; 9 (10 ): 1676-83 PMID25104273 show ga BACKGROUND AND OBJECTIVES: Kidney function gradually decreases with age, and myocardial infarction accelerates this deterioration. Omega-3 (n-3) fatty acids may slow down the decline of kidney function. The effect of marine and plant-derived n-3 fatty acids on kidney function in patients after myocardial infarction was examined. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In the Alpha Omega Trial, 2344 patients with history of myocardial infarction ages 60-80 years old (81% men) were randomized to one of four trial margarines. The patients received an additional targeted amount of 400 mg/d eicosapentaenoic acid and docosahexaenoic acid, 2 g/d ?-linolenic acid, eicosapentaenoic acid-docosahexaenoic acid plus ?-linolenic acid, or placebo for 40 months. Serum cystatin C and serum creatinine were assessed at baseline and after 40 months. Creatinine-cystatin C-based GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation. RESULTS: Patients consumed 19.9 g margarine/d, providing an additional 239 mg/d eicosapentaenoic acid with 159 mg/d docosahexaenoic acid, 1.99 g/d ?-linolenic acid, or both in the active treatment groups. After 40 months, compared with baseline, mean (±SD) creatinine-cystatin C-based GFR was -6.9 (±12.6), -4.8 (±13.4), -6.2 (±12.8), and -6.0 (±13.0) ml/min per 1.73 m(2) in the placebo, eicosapentaenoic acid-docosahexaenoic acid, ?-linolenic acid, and eicosapentaenoic acid-docosahexaenoic acid plus ?-linolenic acid groups, respectively. After 40 months, in patients receiving eicosapentaenoic acid-docosahexaenoic acid compared with placebo, the decline in creatinine-cystatin C-based GFR was 2.1 less (95% confidence interval, 0.6 to 3.6; P<0.01) ml/min per 1.73 m(2); other comparisons were not statistical significant. Odds ratios (95% confidence intervals) of incident CKD (<60 ml/min per 1.73 m(2)) and rapid decline of kidney function (?3 ml/min per year) for eicosapentaenoic acid-docosahexaenoic acid compared with placebo were 0.83 (0.58 to 1.18) and 0.85 (0.67 to 1.08), respectively. CONCLUSIONS: Long-term supplementation with 400 mg/d eicosapentaenoic acid-docosahexaenoic acid provides a small beneficial effect on kidney function in patients with a history of myocardial infarction. |*Food, Fortified [MESH] |*Glomerular Filtration Rate [MESH] |*Margarine [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Biomarkers/blood [MESH] |Chi-Square Distribution [MESH] |Creatinine/blood [MESH] |Cystatin C/blood [MESH] |Disease Progression [MESH] |Docosahexaenoic Acids/*administration & dosage [MESH] |Double-Blind Method [MESH] |Eicosapentaenoic Acid/*administration & dosage [MESH] |Female [MESH] |Humans [MESH] |Kidney/*physiopathology [MESH] |Logistic Models [MESH] |Male [MESH] |Middle Aged [MESH] |Models, Biological [MESH] |Myocardial Infarction/complications/diagnosis/*diet therapy/physiopathology [MESH] |Netherlands [MESH] |Odds Ratio [MESH] |Renal Insufficiency, Chronic/diagnosis/*etiology/physiopathology [MESH] |Risk Factors [MESH] |Time Factors [MESH] |Treatment Outcome [MESH]Effect of omega-3 fatty acids on kidney function after myocardial infa(epmc).pdf DeepDyve Pubget Overpricing