Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.1400732 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400732 C4185228!4185228!25230753     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 193 (8): 4043-52 Nephropedia Template TP {{tp|p=25230753|t=2014. IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation |pdf=|usr=}}{{25230753}} gab.com Text IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25230753 #FOAvip Eosinophils originate in the bone marrow from an eosinophil lineage?committed, IL-5 receptor alpha (IL-5R?)?positive, hematopoietic progenitor (eosinophil progenitor). Indeed, IL-5 is recognized as a critical regulator of eosinophilia and has effects on eosinophil progenitors, eosinophil precursors and mature eosinophils. However, substantial levels of eosinophils remain after IL-5 neutralization or genetic deletion, suggesting that there are alternative pathways for promoting eosinophilia. Herein, we investigated the contributory role of IL-5 accessory cytokines on the final stages of eosinophil differentiation. IL-5 stimulation of low-density bone marrow cells resulted in expression of a panel of cytokines and cytokine receptors, including several ligand-receptor pairs. Notably, IL-4 and IL-4R? were expressed by eosinophil precursors and mature eosinophils. Signaling through IL-4R? promoted eosinophil maturation when IL-5 was present, but IL-4 stimulation in the absence of IL-5 resulted in impaired eosinophil survival, suggesting that IL-4 cooperates with IL-5 to promote eosinophil differentiation. In contrast, CCL3, an eosinophil precursor?produced chemokine that signals through CCR1, promotes terminal differentiation of CCR1-positive eosinophil precursors in the absence of IL-5, highlighting an autocrine loop capable of sustaining eosinophil differentiation. These findings suggest that brief exposure to IL-5 is sufficient to initiate a cytokine cooperative network that promotes eosinophil differentiation of low-density bone marrow cells independent of further IL-5 stimulation. Twit Text FOAVip IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25230753 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25230753 #FOAvip English Wikipedia <ref>{{Cite pmid|25230753}}</ref> IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation #MMPMID25230753 Fulkerson PC; Schollaert KL; Bouffi C; Rothenberg ME J Immunol 2014[Oct]; 193 (8): 4043-52 PMID25230753show ga Eosinophils originate in the bone marrow from an eosinophil lineage?committed, IL-5 receptor alpha (IL-5R?)?positive, hematopoietic progenitor (eosinophil progenitor). Indeed, IL-5 is recognized as a critical regulator of eosinophilia and has effects on eosinophil progenitors, eosinophil precursors and mature eosinophils. However, substantial levels of eosinophils remain after IL-5 neutralization or genetic deletion, suggesting that there are alternative pathways for promoting eosinophilia. Herein, we investigated the contributory role of IL-5 accessory cytokines on the final stages of eosinophil differentiation. IL-5 stimulation of low-density bone marrow cells resulted in expression of a panel of cytokines and cytokine receptors, including several ligand-receptor pairs. Notably, IL-4 and IL-4R? were expressed by eosinophil precursors and mature eosinophils. Signaling through IL-4R? promoted eosinophil maturation when IL-5 was present, but IL-4 stimulation in the absence of IL-5 resulted in impaired eosinophil survival, suggesting that IL-4 cooperates with IL-5 to promote eosinophil differentiation. In contrast, CCL3, an eosinophil precursor?produced chemokine that signals through CCR1, promotes terminal differentiation of CCR1-positive eosinophil precursors in the absence of IL-5, highlighting an autocrine loop capable of sustaining eosinophil differentiation. These findings suggest that brief exposure to IL-5 is sufficient to initiate a cytokine cooperative network that promotes eosinophil differentiation of low-density bone marrow cells independent of further IL-5 stimulation. äIL-5 triggers a cooperative cytokine network that promotes eosinophil (epmc).pdf DeepDyve Pubget Overpricing