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10.1158/0008-5472.CAN-14-0927

http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-0927
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C4184983!4184983!25115301
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suck abstract from ncbi


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pmid25115301      Cancer+Res 2014 ; 74 (19): 5449-57
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  • Gangliosides drive the tumor infiltration and function of myeloid-derived suppressor cells #MMPMID25115301
  • Wondimu A; Liu Y; Yan S; Bobb D; Ma JS; Chakrabarti L; Radoja S; Ladisch S
  • Cancer Res 2014[Oct]; 74 (19): 5449-57 PMID25115301show ga
  • While it is now widely appreciated that anti-tumor immunity is critical to impede tumor growth and progression, there remain significant gaps in knowledge about the mechanisms used by tumors to escape immune control. In tumor cells, we hypothesized that one mechanism of immune escape used by tumors involves the synthesis and extracellular shedding of gangliosides, a class of biologically active cell surface glycosphingolipids with known immunosuppressive properties. In this study, we report that tumor cells engineered to be ganglioside-deficient exhibit impaired tumorigenicity, supporting a link between ganglioside-dependent immune escape and tumor outgrowth. Notably, we documented a dramatic reduction in the numbers and function of tumor-infiltrating myeloid-derived suppressor cells (MDSC) in ganglioside-deficient tumors, in contrast to the large MDSC infiltrates seen in ganglioside-rich littermate control tumors. Transient ganglioside reconstitution of the tumor cell inoculum was sufficient to increase MDSC infiltration, supporting a direct connection between ganglioside production by tumor cells and the recruitment of immunosuppressive MDSC into the tumor microenvironment. Our results reveal a novel mechanism of immune escape that supports tumor growth, with broad implications given that many human tumors produce and shed high levels of gangliosides.
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