Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1097/PAI.0000000000000012 http://scihub22266oqcxt.onion/10.1097/PAI.0000000000000012 C4184929!4184929 !25046225     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25046225 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Appl+Immunohistochem+Mol+Morphol 2014 ; 22 (9 ): 642-7 Nephropedia Template TP {{tp|p=25046225 |t=2014. Constitutive expression of HIF-? plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma |pdf=|usr=}}{{25046225 }} gab.com Text Constitutive expression of HIF- plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma JO: Appl Immunohistochem Mol Morphol http://www.kidney.de/pget.php?&tw=1&pmid=25046225 #FOAvip The extensive lipid accumulation occurring in clear-cell renal cell carcinoma (ccRCC) results in a clear-cell cytoplasm. Hypoxia-inducible factor ? (HIF-?) is constitutively expressed in many ccRCC and transcriptionally regulates >100 genes. In a recent breakthrough study, HIF-1? induced ccRCC in transgenic mice. On the basis of these findings, we developed a hypothesis that accounted for HIF-? generation of the clear-cell phenotype. The aim of the present study was to use immunohistochemical staining methods in tissue microarray to determine the extent to which the clear-cell phenotype coincided with HIF-? expression in primary and metastatic ccRCC. In addition, we studied whether the prolyl-hydroxylases (PHD2,3) play a role in promoting the elevated expression of HIF-? in tumor cells. The clear-cell phenotype was observed in all primary and metastatic cases of ccRCC examined. A total of 168 renal cell carcinomas were evaluated by immunohistochemical methods; 141 of the 168 (84%) tumors expressed HIF-? (HIF-1? and/or HIF-2?). In contrast, HIF-? was expressed in only 1 of the 23 (4%) non-ccRCCs. These data supported the hypothesis that in the majority of the tumors HIF-? expression overlapped with the clear-cell phenotype and was indicative of an HIF-?-mediated lipid accumulation. In a smaller percentage of ccRCC cases (16%), HIF-? was not detected in the tumor cells and suggested that lipid accumulation by HIF-?-lipid-independent process. PHD3 was undetectable in both primary and metastatic ccRCC cases. We concluded that the undetectable PHD3 could contribute to the higher HIF-? expression in ccRCC. Twit Text FOAVip Constitutive expression of HIF- plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma ????Appl Immunohistochem Mol Morphol http://www.kidney.de/pget.php?&tw=1&pmid=25046225 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25046225 #FOAvip English Wikipedia <ref>{{Cite pmid|25046225 }}</ref> Constitutive expression of HIF-? plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma #MMPMID25046225 Tóth K ; Chintala S ; Rustum YM Appl Immunohistochem Mol Morphol 2014[Oct]; 22 (9 ): 642-7 PMID25046225 show ga The extensive lipid accumulation occurring in clear-cell renal cell carcinoma (ccRCC) results in a clear-cell cytoplasm. Hypoxia-inducible factor ? (HIF-?) is constitutively expressed in many ccRCC and transcriptionally regulates >100 genes. In a recent breakthrough study, HIF-1? induced ccRCC in transgenic mice. On the basis of these findings, we developed a hypothesis that accounted for HIF-? generation of the clear-cell phenotype. The aim of the present study was to use immunohistochemical staining methods in tissue microarray to determine the extent to which the clear-cell phenotype coincided with HIF-? expression in primary and metastatic ccRCC. In addition, we studied whether the prolyl-hydroxylases (PHD2,3) play a role in promoting the elevated expression of HIF-? in tumor cells. The clear-cell phenotype was observed in all primary and metastatic cases of ccRCC examined. A total of 168 renal cell carcinomas were evaluated by immunohistochemical methods; 141 of the 168 (84%) tumors expressed HIF-? (HIF-1? and/or HIF-2?). In contrast, HIF-? was expressed in only 1 of the 23 (4%) non-ccRCCs. These data supported the hypothesis that in the majority of the tumors HIF-? expression overlapped with the clear-cell phenotype and was indicative of an HIF-?-mediated lipid accumulation. In a smaller percentage of ccRCC cases (16%), HIF-? was not detected in the tumor cells and suggested that lipid accumulation by HIF-?-lipid-independent process. PHD3 was undetectable in both primary and metastatic ccRCC cases. We concluded that the undetectable PHD3 could contribute to the higher HIF-? expression in ccRCC. |*Gene Expression Regulation, Neoplastic [MESH] |Animals [MESH] |Basic Helix-Loop-Helix Transcription Factors/*biosynthesis [MESH] |Carcinoma, Renal Cell/*metabolism/pathology [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*biosynthesis [MESH] |Hypoxia-Inducible Factor-Proline Dioxygenases/biosynthesis [MESH] |Kidney Neoplasms/*metabolism/pathology [MESH] |Mice [MESH] |Neoplasm Metastasis [MESH]Constitutive expression of HIF-? plays a major role in generation of c(epmc).pdf DeepDyve Pubget Overpricing