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10.1158/2159-8290.CD-14-0157 http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-14-0157 C4184920!4184920!25100205     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Discov 2014 ; 4 (10): 1198-213 Nephropedia Template TP {{tp|p=25100205|t=2014. ATM regulates 3-Methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents |pdf=|usr=}}{{25100205}} gab.com Text ATM regulates 3-Methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents JO: Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=25100205 #FOAvip Alkylating agents are a frontline therapy for the treatment of several aggressive cancers including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving normal cells unharmed; increasing therapeutic response while minimizing toxicity. Using a siRNA screen targeting over 240 DNA damage response genes, we identified novel sensitizers to alkylating agents. In particular the base excision repair (BER) pathway, including 3-methylpurine-DNA glycosylase (MPG), as well as ataxia telangiectasia mutated (ATM) were identified in our screen. Interestingly, we identified MPG as a direct novel substrate of ATM. ATM-mediated phosphorylation of MPG was required for enhanced MPG function. Importantly, combined inhibition or loss of MPG and ATM resulted in increased alkylating agent-induced cytotoxicity in vitro and prolonged survival in vivo. The discovery of the ATM-MPG axis will lead to improved treatment of alkylating agent-resistant tumors. Twit Text FOAVip ATM regulates 3-Methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents ????Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=25100205 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25100205 #FOAvip English Wikipedia <ref>{{Cite pmid|25100205}}</ref> ATM regulates 3-Methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents #MMPMID25100205 Agnihotri S; Burrell K; Buczkowicz P; Remke M; Golbourn B; Chornenkyy Y; Gajadhar A; Fernandez NA; Clarke ID; Barszczyk MS; Pajovic S; Ternamian C; Head R; Sabha N; Sobol RW; Taylor MD; Rutka JT; Jones C; Dirks PB; Zadeh G; Hawkins C Cancer Discov 2014[Oct]; 4 (10): 1198-213 PMID25100205show ga Alkylating agents are a frontline therapy for the treatment of several aggressive cancers including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving normal cells unharmed; increasing therapeutic response while minimizing toxicity. Using a siRNA screen targeting over 240 DNA damage response genes, we identified novel sensitizers to alkylating agents. In particular the base excision repair (BER) pathway, including 3-methylpurine-DNA glycosylase (MPG), as well as ataxia telangiectasia mutated (ATM) were identified in our screen. Interestingly, we identified MPG as a direct novel substrate of ATM. ATM-mediated phosphorylation of MPG was required for enhanced MPG function. Importantly, combined inhibition or loss of MPG and ATM resulted in increased alkylating agent-induced cytotoxicity in vitro and prolonged survival in vivo. The discovery of the ATM-MPG axis will lead to improved treatment of alkylating agent-resistant tumors. äATM regulates 3-Methylpurine-DNA glycosylase and promotes therapeutic (epmc).pdf DeepDyve Pubget Overpricing